Fig. 1.

Schematic of the approach used to define biomarkers of drug response from pathway models. A. Specific predictive models for 14 colorectal cancer (CRC) cell lines were built from perturbation data and prior information about network structure (PKN). B. Drug sensitivity data for the same 14 CRC cell lines were retrieved from the Genomics of Drug Sensitivity in Cancer (GDSC) panel in response to 27 different drugs targeting the PKN or first neighbor. C. Elastic Net was used to select strong associations between model parameters and drug sensitivity.