| Study | Reason for exclusion |
|---|---|
| Adde 2004 | Not timing of dornase alfa. |
| Bakker 2011 | Not timing of dornase alfa. |
| Ballmann 2002 | Not timing of dornase alfa. |
| Bollert 1999 | Not an RCT, not dornase alfa, not timing of dornase alfa. |
| Dodd 2000 | Not timing of dornase alfa. |
| Frederiksen 2006 | Not timing of dornase alfa. |
| Fuchs 1994 | Timing of dornase alfa not addressed by the study. |
| Furuya 2001 | Timing of dornase alfa not addressed by the study. |
| Grassemann 2004 | Timing of dornase alfa not addressed by the study. |
| Griese 1997 | Timing of dornase alfa not addressed by the study. |
| Hagelberg 2008 | Timing of dornase alfa not addressed by the study. |
| Heijerman 1995 | Timing of dornase alfa not addressed by the study. |
| Hjelte 1997 | Timing of dornase alfa not addressed by the study. |
| Hubbard 1992 | Timing of dornase alfa not addressed by the study. |
| Lahiri 2012 | Timing of dornase alfa not addressed by the study. |
| Laube 1996 | Timing of dornase alfa not addressed by the study. |
| Laube 2005 | Timing of dornase alfa not addressed by the study. |
| Mainz 2008 | Timing of dornase alfa not addressed by the study. |
| Mainz 2010 | Timing of dornase alfa not addressed by the study. |
| Majaesic 1996 | Timing of dornase alfa not addressed by the study. |
| Malfroot 1999 | Dornase alfa not assessed in the study. |
| McCoy 1996 | Timing of dornase alfa not addressed by the study. |
| Minasian 2010 | Timing of dornase alfa not addressed by the study. |
| Nasr 2001 | Timing of dornase alfa not addressed by the study. |
| Quan 2001 | Timing of dornase alfa not addressed by the study. |
| Ramsey 1993 | Timing of dornase alfa not addressed by the study. |
| Ranasinha 1993 | Timing of dornase alfa not addressed by the study. |
| Riethmueller 2006 | Not CF participants, timing of dornase alfa not addressed in the study. |
| Robinson 2000 | Timing of dornase alfa not addressed by the study. |
| Robinson 2003 | Timing of dornase alfa not addressed by the study. |
| Sanders 2015 | Not an RCT |
| Sawicki 2015 | Timing of dornase alfa not addressed by the study |
| Shah 1994a | Timing of dornase alfa not addressed by the study. |
| Shah 1994b | Timing of dornase alfa not addressed by the study. |
| Shah 1995a | Not an RCT, timing of dornase alfa not addressed by the study. |
| Shah 1995b | Timing of dornase alfa not addressed by the study. |
| Shah 1995c | Timing of dornase alfa not addressed by the study. |
| Smith 1994 | Timing of dornase alfa not addressed by the study. |
| Suri 2001a | Timing of dornase alfa not addressed by the study. |
| ten Berge 1999 | Timing of dornase alfa not addressed by the study. |
| ten Berge 2003 | Timing of dornase alfa not addressed by the study. |
| Ungewitter 2000 | Timing of dornase alfa not addressed by the study. |
| Weck 1999 | Not an RCT, timing of dornase alfa not addressed in the study. |
| Wilmott 1996 | Timing of dornase alfa not addressed by the study. |
| Wilson 2007 | Does not fit the timing interventions specified in this version of the protocol. Likely inclusion as a new timing intervention in future updates. PEDro 6/10 (Eligibility criteria: yes; random allocation: yes; concealed allocation: yes; baseline comparability: no; blind participants: no; blind therapists: no; blind assessors: yes; adequate follow‐up: yes; ITT analysis: no; between‐group comparisons: yes; point estimates and variability: yes). |
CF: cystic fibrosis RCT: randomised controlled trial