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. 2019 Mar 25;14(3):e0214081. doi: 10.1371/journal.pone.0214081

Table 2. Multiple regression analysis of the HOMA-Adiponectin and HOMA-IR with clamp-derived insulin sensitivity index.

Dependent variable Model Independent variables B 95% CI P-value R2 for model
ISI, mg/kgLBM-1. min-1 per mU/L x 100a,b 1 HOMA-Adiponectina -0.441 -0.581 to -0.300 < 0.001 0.471
Sexc 0.083 -0.065 to 0.231 0.264
Tanner staged -0.122 -0.276 to 0.032 0.117
2 HOMA-Adiponectina -0.349 -0.506 to -0.192 < 0.001 0.521
Sexd 0.123 -0.23 to 0.269 0.097
Tanner staged -0.125 -0.273 to 0.023 0.096
Waist circumference-to-height ratio -1.018 -1.907 to -0.128 0.026
3 HOMA-IRa -1.049 -1.282 to -0.817 < 0.001 0.638
Sexd -0.011 -0.135 to 0.113 0.856
Tanner staged 0.008 -0.125 to 0.142 0.899
4 HOMA-IRa -0.968 -1.259 to -0.676 < 0.001 0.644
Sexd 0.011 -0.122 to 0.145 0.867
Tanner staged -0.003 -0.138 to 0.133 0.968
Waist circumference-to-height ratio -0.384 -1.207 to 0.439 0.353

Abbreviations: B, unstandardized coefficient; CI, confidence interval; ISI, insulin sensitivity index; LBM, lean body mass; HOMA-Adiponectin, homeostasis model assessment of adiponectin; HOMA-IR, homeostasis model assessment of insulin resistance; NA, not applicable

aLogarithmic transformation was performed.

bInsulin sensitivity index (ISI) expressed as milligrams of glucose infused per kilogram of lean body mass (LBM) per minute.

c0 represents the female and 1 the male.

d0 represents the postpubertal stage and 1 the pubertal stage