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. Author manuscript; available in PMC: 2019 Mar 25.
Published in final edited form as: Acc Chem Res. 2017 Sep 11;50(10):2569–2576. doi: 10.1021/acs.accounts.7b00330

Figure 2.

Figure 2.

Substrate evolution and recognition sequence- (RS)-enzyme pairing in cyanobactin pathways. The precursor peptides from the same pathway are often 100% identical, except for the core peptides (blue), which are hypervariable. RS elements in the precursor pathway pair with their cognate modifying enzymes, as indicated by paired colors. Enzymes are also commonly 100% identical within pathways, even though the core peptides are hypervariable. By pairing with conserved recognition sequence, enzymes are able to modify hypervariable cores.