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Representative plasma concentration-time profiles of MX in patients. (A) Dosing regimen: MX (iv continuous infusion), 15 mg/m2/day for 5 days; TMZ (oral once daily), 100 mg/m2/day for 5 days. (B) Dosing regimen: MX (single 1-h iv infusion), 15 mg/m2/day; and TMZ (oral once daily), 100 mg/m2/day for 5 days.
