Table 1.

Accuracy and precision of MX at LLOQ in six patients’ pre-dosed plasmas (n = 5)

Pre-dosed patient plasma	Nominal [MX] (ng/ml)	Measured [MX] (ng/ml)	SD (ng/ml)	%CV	%RE
#1	1.25	1.26	0.04	3	0.8
#2	1.25	1.23	0.03	2	−2
#3	1.25	1.24	0.02	2	−0.8
#4	1.25	1.29	0.03	2	3
#5	1.25	1.21	0.03	2	−3
#6	1.25	1.23	0.04	3	−2
Meana	1.25	1.24	0.01	0.8	−0.8

^aX = (x₁ + x₂ + …x₆)/6; $SD=\left(\sqrt{(s{d}_1^2+s{d}_2^2+s{d}_3^2+s{d}_4^2+s{d}_5^2+s{d}_6^2}\right)/6$; %CV =SD/X; %RE = [(measured value − nominal value)/(nominal value)] × 100%