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. Author manuscript; available in PMC: 2019 Mar 25.
Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 6;901:25–33. doi: 10.1016/j.jchromb.2012.05.036

Table 3.

Matrix effect on MX QC samples in the pooled blank human plasma (n = 5)

MX QC (ng/ml) PAMX in plasma ± SD (x 105) PAMX in extracted plasma ± SD (x 105) RecoveryMX ± SD (%)a PAIS in plasma ± SD (x 105) PAIS in extracted plasma ± SD (x 105) RecoveryIS ± SD (%)b IS Normalized Recovery ± SD (%)c
3.50  0.40 ± 0.03 0.40 ± 0.02 100 ± 9 5.6 ± 0.4 5.7 ± 0.2 98 ± 8 102 ± 12
45.0 5.7 ± 0.3 6.8 ± 0.3 84 ± 6 6.3 ± 0.3 7.5 ± 0.4 84 ± 6 100 ± 10
450 49.8 ± 0.6 52.0 ± 0.5 96 ± 1 5.7 ± 0.1 6.00 ± 0.09 95 ± 2 101 ± 2
a

Recovery of MX = [(PA of MX in plasma matrix)/(PA of MX in extracted plasma matrix)] × 100%

b

Recovery ofIS = [(PA of IS in plasma matrix)/(PA of IS in extracted plasma matrix)] × 100%

c

IS normalized recovery = [(Recovery of MX)/(Recovery of IS)] × 100%.