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. 2019 Mar 25;8:e44527. doi: 10.7554/eLife.44527

Figure 1. Prolonged food-deprivation leads to more pronounced changes in rodent physiology.

(A–F) 18 hr food restriction reduced body weight (A), fat mass (B), lean mass (C), and tissue weights of inguinal WAT, epididymal WAT, quadriceps, gastrocnemius, liver and stomach (D) in both males and female mice, and was further accentuated following 48 hr restriction. Data points outlined in black indicate males; n = 5, Data points outlined in pink indicate females; n = 5 per group, values are means ± SEM. *p<0.05, **p<0.01, ***p<0.001.

Figure 1.

Figure 1—figure supplement 1. Prolonged food-deprivation leads to more pronounced changes in rodent physiology.

Figure 1—figure supplement 1.

(A) Schematic of appetite states used for evaluations. (B) Overall body weight changes of animals at the start of the experiment compared to the time of dissection. Food restriction markedly lowered concentrations of glucose (C), triacylglycerol (C), insulin (C), lactate (D) and leptin (E) while elevating levels of free fatty acids (D), beta-hydroxybutyrate (D), corticosterone (E) and liver triacylglycerol (F). Data points outlined in black indicate males; n = 5, Data points outlined in pink indicate females; n = 5 per group, values are means ± SEM. *p<0.05, **p<0.01, ***p<0.001.