Table 3.

Analyses of cumulative expected lead and ALS case status in men

	Controls N (%)	Cases N (%)	OR (95% CI)*	aOR (95% CI)†
No lag (n=93 508)
No exposure	78 975 (85.36)	827 (83.87)	1.00 (Ref)	1.00 (Ref)
Ever exposure (μmol/L)‡	13 547 (14.64)	159 (16.13)	1.13 (0.95 to 1.33)	1.15 (0.96 to 1.38)
<50.00	3172 (3.43)	37 (3.75)	1.19 (0.85 to 1.68)	1.20 (0.85 to 1.69)
50.00–222.00	3269 (3.53)	33 (3.35)	0.92 (0.63 to 1.34)	0.93 (0.63 to 1.35)
>222.00	7106 (7.68)	89 (9.30)	1.22 (0.97 to 1.53)	1.23 (0.99 to 1.55)
Test for trend			1.01 (0.99 to 1.02)	1.00 (0.99 to 1.02)
5-year lag
No exposure	81 107 (87.66)	848 (86.00)	1.00 (Ref)	1.00 (Ref)
Ever exposure (μmol/L)‡	11 415 (12.34)	138 (14.00)	1.16 (0.97 to 1.39)	1.19 (0.98 to 1.44)
<50.00	3276 (3.54)	39 (3.96)	1.14 (0.83 to 1.58)	1.22 (0.87 to 1.70)
50.00–222.00	3348 (3.62)	32 (3.25)	0.92 (0.65 to 1.31)	0.93 (0.64 to 1.35)
>222.0	4791 (5.18)	67 (6.80)	1.35 (1.05 to 1.73)	1.35 (1.04 to 1.76)
Test for trend			1.02 (0.99 to 1.04)	1.01 (0.99 to 1.04)
10-year lag
No exposure	81 802 (88.41)	858 (87.02)	1.00 (Ref)	1.00 (Ref)
Ever exposure (μmol/L)‡	10 720 (11.59)	128 (12.98)	1.15 (0.95 to 1.38)	1.16 (0.95 to 1.41)
<50.00	3208 (3.47)	37 (3.75)	1.11 (0.80 to 1.54)	1.16 (0.83 to 1.64)
50.00–222.00	3223 (3.48)	32 (3.25)	0.95 (0.67 to 1.36)	0.95 (0.65 to 1.38)
>222.00	4289 (4.64)	59 (5.98)	1.32 (1.01 to 1.73)	1.33 (1.03 to 1.72)
Test for trend			1.01 (0.99 to 1.05)	1.01 (0.98 to 1.04)

Bold values are statistically significant (p <0.05)

^*Controls were individually matched to cases on age and sex.

^†Models adjusted for SES and residential location.

^‡Cumulative expected exposure=level of exposure*days employed for jobs with >50% probability of exposure.

ALS, amyotrophic lateral sclerosis; aOR, adjusted OR; SES, socioeconomic status.