Figure 3. Calcium source and ${\stackrel{-}{\mathit{g}}}_{\mathit{C}\mathit{A}\mathit{N}}$-dependent effects on cellular properties regulating network activity amplitude for the simulations presented in Figure 1.

(A) Number of recruited neurons in the modeled population of 100 neurons as a function of ${\stackrel{-}{\mathit{g}}}_{\mathit{C}\mathit{A}\mathit{N}}$ (%) for voltage-gated and synaptic calcium sources. The number of recruited neurons is defined as the peak number of spiking neurons per bin during a network burst. (B) Average spiking frequency of recruited neurons as a function of ${\stackrel{-}{\mathit{g}}}_{\mathit{C}\mathit{A}\mathit{N}}$ for the voltage-gated and synaptic calcium mechanism. Average spiking frequency is defined the number of spikes per bin divided by the number of recruited neurons. The parameters used in these simulations are: ${\mathit{C}\mathit{a}}_{\mathit{V}}$: ${\stackrel{-}{\mathit{g}}}_{\mathit{C}\mathit{a}}=1.0\mathit{}\left(\mathit{n}\mathit{S}\right)$, ${\mathit{P}}_{\mathit{C}\mathit{a}}=0.0$, ${\mathit{P}}_{\mathit{S}\mathit{y}\mathit{n}}=0.05$ and ${\displaystyle {\mathit{W}}_{\mathit{m}\mathit{a}\mathit{x}}=0.2\left(\mathit{n}\mathit{S}\right)}$. ${\mathit{C}\mathit{a}}_{\mathit{S}\mathit{y}\mathit{n}}$: ${\stackrel{-}{\mathit{g}}}_{\mathit{C}\mathit{a}}=0\mathit{}\left(\mathit{n}\mathit{S}\right)$, ${\mathit{P}}_{\mathit{C}\mathit{a}}=0.01$, ${\mathit{P}}_{\mathit{S}\mathit{y}\mathit{n}}=0.05$ and ${\displaystyle {\mathit{W}}_{\mathit{m}\mathit{a}\mathit{x}}=0.2\left(\mathit{n}\mathit{S}\right)}$.