. Author manuscript; available in PMC: 2020 Apr 1.

Published in final edited form as: Trends Pharmacol Sci. 2019 Feb 28;40(4):253–266. doi: 10.1016/j.tips.2019.02.004

Table 1.

Role of MSTFs in atherosclerosis in vivo

Animal model	Effect on atherosclerosis	Observed atherosclerotic characteristics	References
KLF2^+/−; ApoE^−/− mice	↑	↑ Foam cell formation	[36]
KLF2 ^ΔMye; LDLR^−/− mice	↑	↑ Lesional neutrophils and macrophages	[38]
KLF4 ^ΔEC; ApoE^−/−	↑	↑ Endothelial inflammation and thrombosis	[35]
KLF4^Tg(EC); ApoE^−/−	↓	↓ Endothelial inflammation and thrombosis	[35]
NRF2^−/−; ApoE^−/−	↓	↓ Foam cell formation	[95, 96]
NRF2^−/−; LDLR^−/− ApoB 100/100	Mixed	↓ Atherosclerotic lesion size ↑ Atherosclerotic plaque vulnerability	[97]
NF-kB^ΔEC; ApoE^−/−	↓	↓ Adhesion molecules and inflammation	[63]
I-κBmt^OE(EC); ApoE^−/−	↓	↓ Chronic intermittent hypoxia induced atherosclerosis; NF-kB activity	[64]
HIF-1α^ΔEC; ApoE^−/−	↓	↓ Monocyte adhesion	[61]
HIF-1α^ΔMye; ApoE^−/−	↓	↓ Inflammatory gene expression	[98]
YAP/TAZ^KD; ApoE^−/−	↓	↓ Promotes EC proliferation, inflammation	[27]
YAP^{OE (EO)}; ApoE^−/−; YAP^{Tg (EC)}; ApoE^−/−; YAP/TAZ^CA; ApoE^−/−	↑	↑ Monocyte adhesion, macrophage accumulation	[26]
YAp^{OE (EC)}; ApoE^−/−	↑	↑ VCAM1 dependent monocyte adhesion	[28]

Abbreviations:

KD, knockdown; OE (EC), endothelial cell-specific overexpression; Tg (EC), endothelial cell specific transgene; ΔMye, myeloid cell-specific knockout; ΔEC, endothelial cell-specific knockout