Table 2.

Examples of atheroprotective drugs that target MSTFs

Name of drug	Effect on atherosclerosis	Targeted MSTFs	References
Statins	↓	(+) KLF2; (+) KLF4; (+) NRF2; (−) NF-κB; (−) AP1; (−) YAP/TEAD; (−) HIF-1α	[26, 27, 66, 67, 99-102]
Resveratrol	↓	(+) KLF2; (+) KLF4; (+) NRF2; (−) NF-κB	[22, 68, 69, 103, 104]
Tannic acid	↓	(+) KLF2	[71, 72]
SAHA	↓	(+) KLF2	[70]
Sulforaphane	↓	(+) NRF2; (−) NF-κB	[75, 105]
Verteporfin	↓	(−) YAP/TEAD	[77, 78]
Evodiamine	↓	(−) HIF-1α	[79, 106]
Digoxin	↓	(−) HIF-1α	[80, 81]
2-Methoxyestradiol	↓	(−) HIF-1α	[82, 83]

(+) activate; (−) inhibit.