Table 1:
Characteristics of patients suspected for chronic rejection after face vascularized composite tissue transplantation compared to all patients of the Brigham and Women’s Hospital face transplant cohort. Tx – transplantation; CR – chronic rejection; AR – acute rejection; Tac – Tacrolimus; MMF – Mycophenolate mofetil; Pred – Prednisone; Myf – Myfortic; Sir - Sirolimus; Bela - Belatacept
| Mean | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | |
|---|---|---|---|---|---|---|---|---|
| Type of Transplant | Full Face | Full Face | Partial Face | Full Face | Full Face | Partial Face | Partial Face | |
| Initial injury | Chimpanzee attack | Electrical Burn | Electrical Burn | Electrical Burn | Acid Burn | Ballistic Trauma | Ballistic Trauma | |
| Age at Tx | 47 (±19.1) | 57 | 25 | 59 | 30 | 44 | 39 | 33 |
| Donor age | 50 (±9.2) | 42 | 48 | 60 | 31 | 56 | 23 | 51 |
| Sex | female | male | male | male | female | male | male | |
| Signs of chronic rejection | Yes | Yes | Yes | No | No | No | No | |
| Time to CR in months | 46 (±21.5) | 45 | 25 | 68 | - | - | - | - |
| Total time post-transplantion | 76,4 (±23.5) | 86 | 88 | 112 | 87 | 65 | 45 | 52 |
| Total # AR episodes | 4,4 (±1.3) | 4 | 5 | 4 | 5 | 6 | 2 | 5 |
| # AR episodes before CR | 2(±1) | 2 | 1 | 3 | - | - | - | - |
| Donor Specific Antibodies | No | No | No | No | Yes | No | No | |
| Immunosuppression | Tac, Sir, Myf | Tac, MMF, Pred | Tac, MMF, Pred | Tac, MMF, Pred | Tac, MMF, Pred | Tac, MMF | Tac, MMF, Pred, Bela |