Table 2:
Gene expression of non-rejection, acute and chronic rejection samples. Table S2 shows the top 20 genes with fold changes greater than twofold for chronic rejection (CR) vs non rejection (NR), acute rejection (AR) vs NR, and CR vs AR. Expression profiles were assessed using 840 gene containing panCancer immune Nanostring panel. FOS, aka c-Fos as part of AP-1 pathway, appears to associate with CR.
| CR vs NR | AR vs NR | CR vs AR | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Fold Change | Adj. p | Gene | Fold Change | Adj. p | Gene | Fold Change | Adj. p | ||||
| FOS | 2.62 | NA | ↑ | CXCL11 | 3.74 | 0.0044 | ↑ | FOS | 2.19 | NA | ||
| CXCL11 | 2.29 | 0.3000 | ISG15 | 3.61 | 0.0044 | |||||||
| MX1 | 2.28 | 0.2714 | MX1 | 3.43 | 0.0044 | |||||||
| CXCL1 | 2.26 | 0.2714 | CCL19 | 3.28 | 0.0044 | |||||||
| C1QB | 2.17 | 0.2714 | ITGAX | 3.13 | 0.0012 | |||||||
| IFITM1 | 2.16 | 0.2714 | IFIT1 | 2.94 | 0.0066 | |||||||
| IFI27 | 2.14 | 0.2714 | CD83 | 2.94 | 0.0108 | |||||||
| FCGR2A | 2.12 | 0.2714 | CTLA4 | 2.93 | 0.0087 | |||||||
| SERPINB2 | 2.11 | 0.1289 | LY9 | 2.84 | 0.0012 | |||||||
| C3 | 2.11 | NA | PTPRC | 2.80 | 0.0044 | |||||||
| CD209 | 2.10 | 0.2714 | KLRK1 | 2.78 | 0.0044 | |||||||
| CCL8 | 2.06 | 0.3565 | CCL8 | 2.76 | 0.0108 | |||||||
| MSR1 | 2.06 | 0.2714 | PRF1 | 2.76 | 0.0102 | |||||||
| OAS3 | 2.05 | 0.2714 | SELPLG | 2.74 | 0.0048 | |||||||
| STAT1 | 2.02 | 0.2714 | IRF1 | 2.74 | 0.0087 | |||||||
| CD3E | 2.02 | 0.3822 | MSR1 | 2.73 | 0.0036 | |||||||
| BST2 | 2.70 | 0.0044 | ||||||||||
| IL2RG | 2.67 | 0.0108 | ||||||||||
| STAT1 | 2.64 | 0.0061 | ||||||||||
| IRF4 | 2.63 | 0.0044 | ||||||||||