Table 3.

Multivariable cox regression of cSS presence and other potential predictors of first-ever symptomatic lobar intracerebral hemorrhage.

Variables	HR (95%CI)	p-value
a. Main model (any cSS progression)
Age, per year increase	1.08 (1–1.16)	0.045
Any cSS progression (vs. no progression)	3.76 (1.37–10.35)	0.010
New lobar CMBs (Yes vs. No)	0.95 (0.30–3)	0.926
b. Sensitivity analysis model (severity of cSS progression)
Age (for each year increase)	1.11 (1.02–1.20)	0.016
cSS progression in the same focus/1 new focus	1.21 (0.22–6.57)	0.823
cSS progression ≥2 new foci	7.90 (2.47–25.21)	<0.0001
New lobar CMBs (Yes vs. No)	0.76 (0.23–2.46)	0.644

Both models remain consistent/similar effect sizes when additionally adjusted for differences in baseline and follow-up blood-sensitive MRI sequences, sex, cSS presence at baseline and MRI interval (months).