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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Trends Pharmacol Sci. 2019 Mar 11;40(4):278–293. doi: 10.1016/j.tips.2019.02.003

Figure 3: Domain-specific functions of ADGRG6.

Figure 3:

The NTF attachment of ADGRG6 to its CTF suppresses receptor activity, thereby maintaining Schwann cells in an immature state and allowing for radial sorting of cells to axons. Increased accumulation and binding of its ligand laminin-211 removes the NTF, thereby allowing for Stachel-dependent activation of ADGRG6, association with Gαs, accumulation of cyclic AMP (cAMP), and the initiation of cAMP-dependent myelinogenic gene programs and the myelination of peripheral axons. Adapted from [30].