. Author manuscript; available in PMC: 2020 Apr 1.

Published in final edited form as: Trends Pharmacol Sci. 2019 Mar 11;40(4):278–293. doi: 10.1016/j.tips.2019.02.003

Table 2.

GWAS analysis identifying adhesion GPCRs in neurological diseases.

aGPCR	CNS disease	SNP ID	Chrom osome	Change	MAF	p-value	PubMed ID
ADGRB3 (BAI3)	Late-onset Alzheimer’s	rs10485435	6q	G>T; intronic	0.331	6.1E⁻⁷	21390209
	Autism	rs13208283	6q	A>C; intronic	0.042	1.1E⁻⁶	20663923
	Autism	rs16900553	6q	A>C; intronic	0.141	5.2E⁻⁶	20663923
	Schizophrenia	rs3011917	6q	A>C; intronic	0.115	5.1E⁻⁶	21688384
ADGRG1 (GPR56)	Late-onset Alzheimer’s	rs1466134	16q	G>A; intronic	0.319	8.0E⁻⁶	21379329
ADGRG1 (GPR56)	Multiple Sclerosis	rs1376041	16q	996T>C	0.241	7.3E⁻⁶	19525953
ADGRC1 (CELSR1)	Myopia	rs3827410	22q	C>A; intronic	0.430	9.9E⁻⁶	21640322; 23406873

SNP data was collected using the NIH GRASP database, applying a p-value cutoff of p<1E⁻⁶ and within neurological disorders. MAF: minor allelic frequency.