Table 3.
Adjusted Hazard Ratios (95% CI) for Mental Illness in Colorectal Cancer Survivors (11-11-18 Update)
| 0-2 Years after Cancer Diagnosis | 2-5 Years after Cancer Diagnosis | 5+ Years after Cancer Diagnosis | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cancer Cases | Gen. | Cancer Cases | Gen. | Cancer Cases | Gen. | ||||||||||
| Diagnosis (CCS Code) | n | % | n | % | Adj. HR (95% CI) | n | % | n | % | Adj. HR (95% CI) | n | % | n | % | Adj. HR (95% CI) |
| Mental Illness (5) | 1,517 | 24.8 | 2,340 | 8.7 | 3.70 (3.47, 3.95) | 437 | 12.8 | 1,961 | 11.4 | 1.23 (1.09, 1.38) | 541 | 26.9 | 2,031 | 21.7 | 1.2 (1.07, 1.36) |
| Adjustment disorders (5.1) | 54 | 0.61 | 73 | 0.2 | 3.56 (2.49, 5.09) | 23 | 0.37 | 52 | 0.21 | 1.76 (1.04, 3.00) | 29 | 0.75 | 56 | 0.4 | 1.99 (1.26, 3.12) |
| Anxiety disorders (5.2) | 522 | 6.4 | 875 | 2.7 | 2.84 (2.55, 3.17) | 214 | 3.98 | 743 | 3.39 | 1.24 (1.06, 1.47) | 321 | 9.68 | 991 | 8 | 1.30 (1.13, 1.50) |
| Delirium dementia and cognitive disorders (5.4) | 319 | 3.7 | 871 | 2.5 | 1.99 (1.72, 2.29) | 159 | 2.67 | 722 | 3.06 | 0.81 (0.67, 0.98) | 346 | 9.28 | 955 | 7.07 | 1.20 (1.03, 1.38) |
| Developmental disorders (5.5) | 46 | 0.5 | 62 | 0.17 | 3.78 (2.41, 5.94) | 27 | 0.43 | 76 | 0.31 | 1.37 (0.85, 2.20) | 33 | 0.84 | 90 | 0.64 | 1.22 (0.78, 1.91) |
| Communication disorders (5.5.1) | 36 | 0.4 | 48 | 0.13 | 4.14 (2.49, 6.90) | 24 | 0.38 | 62 | 0.25 | 1.39 (0.82, 2.34) | 30 | 0.76 | 83 | 0.59 | 1.19 (0.75, 1.90) |
| Mood disorders (5.8) | 643 | 8.2 | 1,106 | 3.5 | 2.98 (2.68, 3.32) | 267 | 5.22 | 939 | 4.48 | 1.18 (1.02, 1.37) | 315 | 10.1 | 1,016 | 8.6 | 1.24 (1.07, 1.43) |
| Bipolar disorders (5.8.1) | 47 | 0.53 | 94 | 0.26 | 1.97 (1.50, 2.59) | 30 | 0.49 | 85 | 0.35 | 1.45 (0.95, 2.21) | 33 | 0.85 | 134 | 0.97 | 1.14 (0.82, 1.58) |
| Depressive disorders (5.8.2) | 629 | 7.94 | 1,087 | 3.42 | 2.62 (2.35, 2.93) | 266 | 5.17 | 927 | 4.41 | 1.17 (1.06, 1.29) | 289 | 9.04 | 683 | 4.74 | 1.21 (1.10, 1.34) |
| Personality disorders (5.9) | 14 | 0.16 | 40 | 0.11 | 1.04 (0.48, 2.23) | 3 | 0.05 | 29 | 0.12 | 0.53 (0.15, 1.89) | 6 | 0.15 | 28 | 0.2 | 0.84 (0.32, 2.17) |
| Schizophrenia and other psychotic disorders | 167 | 1.89 | 339 | .96 | 2.8 (2.21, 3.53) | 81 | 1.33 | 244 | 1.01 | 1.28 (0.97, 1.68) | 161 | 4.2 | 392 | 2.85 | 1.28 (1.03, 1.58) |
| Alcohol-related disorders (5.11) | 109 | 1.25 | 169 | 0.48 | 3.55 (2.69, 4.67) | 42 | 0.69 | 141 | 0.59 | 1.2 (0.83, 1.73) | 51 | 1.34 | 182 | 1.32 | 1.23 (0.88, 1.73) |
| Substance-related disorders (5.12) | 141 | 1.6 | 179 | 0.51 | 5.41 (4.04, 7.25) | 81 | 1.33 | 190 | 0.79 | 1.93 (1.45, 2.56) | 81 | 2.12 | 204 | 1.48 | 1.41 (1.06, 1.87) |
| Suicide and intentional self-inflicted injury | 20 | 0.22 | 72 | 0.2 | 1.28 (0.76, 2.16) | 12 | 0.19 | 64 | 0.26 | 0.74 (0.39, 1.43) | 28 | 0.72 | 89 | 0.64 | 1.19 (0.75, 1.89) |
| Screening and history of MH and SA codes (5.14) | 850 | 11.4 | 905 | 2.8 | 5.70 (5.14, 6.32) | 213 | 4.5 | 813 | 3.76 | 1.28 (1.09, 1.51) | 231 | 7.84 | 893 | 7.32 | 1.18 (1.02, 1.36) |
| Codes related to mental health disorders (5.14.1) | 770 | 9.52 | 654 | 1.92 | 5.85 (5.26, 6.50) | 234 | 4.52 | 634 | 2.77 | 1.75 (1.49, 2.06) | 258 | 8.05 | 803 | 6.17 | 1.37 (1.19, 1.58) |
| Codes related to substance-related disorders | 370 | 4.54 | 457 | 1.35 | 4.45 (3.85, 5.15) | 88 | 1.61 | 393 | 1.73 | 1.00 (0.79, 1.28) | 98 | 2.83 | 373 | 2.88 | 0.97 (0.75, 1.26) |
| Miscellaneous mental disorders (5.15) | 106 | 1.22 | 265 | 0.76 | 2.81 (2.11, 3.74) | 71 | 1.18 | 250 | 1.06 | 1.18 (0.89, 1.57) | 79 | 2.1 | 262 | 1.95 | 1.09 (0.83, 1.44) |
| Eating disorders (5.12.2) | 6 | 0.07 | 16 | 0.04 | 1.81 (0.72, 4.56) | 1 | 0.02 | 7 | 0.03 | 1.33 (0.31, 5.81) | 1 | 0.03 | 12 | 0.09 | 0.27 (0.03, 2.28) |
| Psychogenic disorders (5.15.4) | 8 | 0.09 | 15 | 0.04 | 3.28 (1.23, 8.78) | 5 | 0.08 | 24 | 0.1 | 0.38 (0.09, 1.52) | 8 | 0.2 | 27 | 0.19 | 0.83 (0.31, 2.21) |
| Sleep disorders (5.15.6) | 11 | 0.12 | 37 | 0.1 | 1.49 (0.71, 3.12) | 14 | 0.22 | 42 | 0.17 | 1.32 (0.67, 2.58) | 16 | 0.4 | 52 | 0.37 | 1.02 (0.55, 1.88) |
| Somatoform disorders (5.15.7) | 27 | 0.3 | 72 | 0.2 | 1.79 (1.11, 2.89) | 15 | 0.24 | 84 | 0.35 | 0.69 (0.38, 1.25) | 22 | 0.57 | 78 | 0.56 | 1.10 (0.67, 1.80) |
| Mental disorders due to GMCs(5.15.8) | 35 | 0.39 | 43 | 0.12 | 3.72 (2.28, 6.07) | 14 | 0.22 | 44 | 0.18 | 1.08 (0.56, 2.12) | 22 | 0.56 | 60 | 0.43 | 1.36 (0.80, 2.31) |
| Other miscellaneous mental conditions | 6 | 0.07 | 19 | 0.05 | 1.96 (0.69, 5.54) | 4 | 0.06 | 5 | 0.02 | 1.41 (0.08, 23.6) | 3 | 0.08 | 15 | 0.11 | 0.63 (0.13, 2.99) |
Adjusted for baseline BMI, baseline CCI, and race.