Table 1:

Clinical Characteristics of 9 prepubertal male patients with URA.

Age	Age at Dx	cryptorchidism	anosmia	prematurity	Birth order	UT/ nephro defects	Ass. Abn	Fx of renal agenesis	Fx
6 yo	2.5 m	no	no	no	second	no	no	n/a	Anosmia in both grandfathers
15 yo	7 month of embryonic development	no	no	no	third	ureteropelvic junstion stenosis R, hydronephrosis R, chronic renal failure	no	n/a	Cleft lip and palate in maternal aunt, Psychiatric disorder in two grandparents
6 yo	2nd trimeter	no	no	no	first twin birth	no	no	nl	Depression paternal great uncle
8 yo	2nd trimester	no	no	no	second	no	verbal disorder, speech therapy	nl	T1D father, Nephrolithiasis paternal grandfather, Hypothyroidism paternal grandmother, Hyperthyroidism paternal great uncle, Epilepsy maternal uncle
5 yo	2nd trimester	no	no	no	third	no	no	n/a	Anosmia paternal great grandmother, Kidney malformation in maternal great uncle, Verterbal collum lipoma maternal aunt
6 yo	2nd trimester	cryptorchidiam R-orcheopexy at 18 m	no	no	third	no	no	n/a	T1D maternal aunt, Gastroschisis paternal grate grandfather
11 yo	at birth	no	no	no	third	no	hydrocele L, balanoposthetical adhensions	n/a	Hyposmia paternal great aunt, Skoliosis father, Skoliosis, osteoporosis and Parkinson’s disease in paternal grandfather, Parkinson’s diseasepaternal great uncle, Psoriasis paternal grandmother
6 yo	2nd trimester	no	no	no	second	no	no	brother with URA	Strabismus mother, Hypothyroidism-Thyroidectomy-T2D maternal grandmother
10 yo	9 m	no	no	no	first	hydroureter R, nephrocalycosis R	stravismus	brother with URA	Strabismus mother, Hypothyroidism-Thyroidectomy-T2D maternal grandmother

Table 1 shows the clinical characteristics of the 9 male prepubertal patients analyzed including their age, age at diagnosis, the presence of cryptorchidism, anosmia or prematurity, the birth order, the presence of urinary tract or renal defects, associated abnormalities, family history of unilateral renal agenesis or other diseases and disorders, including reproductive or non-reproductive features of IGD. Dx: Diagnosis, UT: Urinary tract, Ass. Abn: Associated Abnormalities, Fx: Family history, N/a: not available, nl: normal, T1D: type 1 diabetes, T2D: type 2 diabetes.