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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Neuropathol Appl Neurobiol. 2018 Oct 28;45(4):380–397. doi: 10.1111/nan.12518

Table 2.

Neuropathological Characteristics

NCI MCI mAD p-value
Total Neuritic Plaque Count 17.50 [0, 43] 33 [0, 90.25] 55.50 [3, 132.50] 0.18
Total Diffuse Plaque Count 18 [0, 65] 25 [0.75, 52.50] 66 [11.50, 91] 0.23
Total Neurofibrillary Tangle Count 17.50 [7.50, 44] 28 [20.75, 66.50] 44.50 [5.50, 106] 0.28
CERAD Neuropathological Diagnosis
No AD 9 4 3
Possible AD 7 5 2 0.31
Probable AD 2 1 1
Definite AD 2 3 6
Braak Stage
0 1 0 0
I 2 1 2
II 4 0 2 0.17
III 4 5 1
IV 9 5 3
V 0 2 4
NIA Reagan Diagnosis
Not AD 1 0 0 0.37
Low Likelihood 11 6 4
Intermediate Likelihood 8 5 5
High Likelihood 0 2 3

Median [25th %ile, 75th %ile]; AD, Alzheimer’s disease; CERAD, Consortium to Establish a Registry for Alzheimer’s Disease; MCI, mild cognitive impairment; NCI, no cognitive impairment; NIA, National Institute on Aging.