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. 2019 Mar 25;2019(3):CD012387. doi: 10.1002/14651858.CD012387.pub2

3. Evidence summary ‐ continuous outcomes.

Raw data: continuous outcomes
Main outcome Suboutcome Time postintervention Scale used Intervention (screening) Control (usual care) MD (95% CI) Study ID
Mean SD N Mean SD N
HRQoL (continuous) Global health status 1 month EORTC QLQ‐C30 65.18 17.43 28 51.49 26.16 28 13.69 [2.05, 25.33] Bramsen 2008
61.8 20.9 109 61.2 18.2 103 0.60 [−4.67, 5.87] Hollingworth 2013
EQ‐5D 0.739 0.223 109 0.74 0.249 103 −0.00 [−0.06, 0.06]
FACT‐C 107.8 11.9 20 101.2 22.3 21 6.60 [−4.27, 17.47] Young 2010
96.1 18.5 35 98.3 19.7 31 0.21 [−2.47, 2.89] Harrison 2011
100.61 17.78 346 100.4 18.6 363 0.01 [−0.14, 0.16] Young 2013
6 weeks EORTC QLQ‐C30 63.1 25 42 65.5 25 44 −0.10 [−0.52, 0.33] Nimako 2015
65.4 20.825 45 65.5 25 44 −0.00 [−0.42, 0.41]
2 months 57.5 4.74 103 58 4.75 192 −0.11 [−0.34, 0.13] Waller 2012
3 months EORTC QLQ‐C30 72.61 20.08 268 71.48 19.62 300 0.06 [−0.11, 0.22] Braeken 2013
FLIC 116.5 21.1 60 114.1 24.7 60 0.10 [−0.23, 0.44] Rosenbloom 2007
112.1 20.6 60 114.1 24.7 60 −0.09 [−0.41, 0.24]
FACT‐C 114.2 13.5 20 101.5 19.1 21 0.75 [0.11, 1.39] Young 2010
97.5 21.4 34 96.2 21.9 29 0.06 [−0.44, 0.55] Harrison 2011
103.48 18.17 336 103.26 18.58 351 0.01 [−0.14, 0.16] Young 2013
4 months EORTC QLQ‐C30 56.5 5.09 85 58 4.75 192 −0.31 [−0.56, −0.05] Waller 2012
6 months 69.3 22.14 281 68 21.89 297 0.06 [−0.10, 0.22] Bergholdt 2013
77 16 80 80 18 80 −0.18 [−0.49, 0.14] de Leeuw 2013
68.6 17.7 108 68.3 18.2 101 0.02 [−0.25, 0.29] Hollingworth 2013
57.5 5.39 67 58 4.75 192 −0.10 [−0.38, 0.18] Waller 2012
EQ‐5D 0.783 0.217 108 0.79 0.246 103 −0.03 [−0.30, 0.24] Hollingworth 2013
FLIC 115.8 22.9 51 112.2 21.4 52 0.16 [−0.17, 0.49] Rosenbloom 2007
113.3 24.5 51 112.2 21.4 52 0.05 [−0.28, 0.37]
FACT‐C 106 19.3 28 98.6 23.4 30 0.34 [−0.18, 0.86] Harrison 2011
105.1 17.88 322 105.35 19.5 350 −0.01 [−0.16, 0.14] Young 2013
12 months EORTC QLQ‐C30 75.95 18.7 268 76.09 17.53 300 −0.01 [−0.17, 0.16] Braeken 2013
81 18 80 80 17 80 0.06 [−0.25, 0.37] de Leeuw 2013
68.5 20.2 106 69.6 20.4 103 −0.05 [−0.33, 0.22] Hollingworth 2013
EQ‐5D 0.742 0.268 106 0.788 0.257 103 −0.17 [−0.45, 0.10]
14 months EORTC QLQ‐C30 72.1 19.66 240 72.8 19.71 246 −0.04 [−0.21, 0.14] Bergholdt 2013
4th follow‐up visit SF‐36 46 N/A 108 47 N/A 110 N/E Hilarius 2008
Physical functioning 1 month EORTC QLQ‐C30 80.48 20.84 28 63.63 23.42 28 16.85 [5.24, 28.46] Bramsen 2008
81.9 20.5 109 80.7 20.5 103 1.20 [−4.32, 6.72] Hollingworth 2013
FACT‐C 22.8 3.3 20 21.8 5.1 21 1.00 [−1.62, 3.62] Young 2010
6 weeks EORTC QLQ‐C30 74.6 21.675 42 72.2 21.675 43 2.40 [−6.82, 11.62] Nimako 2015
73.8 25 43 72.2 21.675 43 1.60 [−8.29, 11.49]
2 months 57.21 30.33 55 60.2 29.99 53 −2.99 [−14.37, 8.39] Schofield 2013
3 months 79.63 21.02 268 81.78 17.83 300 −2.15 [−5.38, 1.08] Braeken 2013
63.49 27.66 55 59.09 26.57 53 4.40 [−5.83, 14.63] Schofield 2013
FLIC 45.9 12 69 45.7 11.9 71 0.20 [−3.76, 4.16] Rosenbloom 2007
44.5 10.4 60 45.7 11.9 60 −1.20 [−5.20, 2.80]
FACT‐C 24.4 3.2 20 22.1 5.2 21 2.30 [−0.33, 4.93] Young 2010
6 months EORTC QLQ‐C30 79.7 22.1 280 79 22.65 294 0.70 [−2.96, 4.36] Bergholdt 2013
83 17 80 86 16 80 −3.00 [−8.12, 2.12] de Leeuw 2013
84.2 19 108 83.8 18.6 101 0.40 [−4.70, 5.50] Hollingworth 2013
FLIC 46.7 11.6 51 45.2 9.8 52 1.50 [−2.65, 5.65] Rosenbloom 2007
45 20.6 51 45.2 9.8 52 −0.20 [−6.45, 6.05]
12 months EORTC QLQ‐C30 81.99 18.06 268 85 17.76 300 −3.01 [−5.96, −0.06] Braeken 2013
86 17 80 87 16 80 −1.00 [−6.12, 4.12] de Leeuw 2013
83.8 19.3 106 85.5 17.8 103 −1.70 [−6.73, 3.33] Hollingworth 2013
14 months 82 20.19 234 81.9 20.45 240 0.10 [−3.56, 3.76] Bergholdt 2013
4th follow‐up visit SF‐36 53 28 104 52 26 95 1.00 [−6.50, 8.50] Detmar 2002
69 N/A 108 62 N/A 110 N/E Hilarius 2008
Role functioning 1 month EORTC QLQ‐C30 57.14 27.75 28 39.88 35.35 28 17.26 [0.61, 33.91] Bramsen 2008
69.4 31.3 109 68 28.8 103 1.40 [−6.69, 9.49] Hollingworth 2013
FACT‐C 13.8 6.1 20 12.1 5.8 21 1.70 [−1.95, 5.35] Young 2010
6 weeks EORTC QLQ‐C30 70.63 25 42 69.7 25 44 0.93 [−9.64, 11.50] Nimako 2015
62.5 25 44 69.7 25 44 −7.20 [−17.65, 3.25]
2 months 57.03 36.71 55 56.82 35.82 53 0.21 [−13.47, 13.89] Schofield 2013
3 months 72.77 29.77 268 72.87 27.52 300 −0.10 [−4.83, 4.63] Braeken 2013
58.48 36.86 55 65.01 35.16 53 −6.53 [−20.11, 7.05] Schofield 2013
FACT‐C 21.4 4.8 20 17.4 7.3 21 4.00 [0.24, 7.76] Young 2010
6 months EORTC QLQ‐C30 72.5 31.28 277 71.3 31.2 291 1.20 [−3.94, 6.34] Bergholdt 2013
79 26 80 81 24 80 −2.00 [−9.75, 5.75] de Leeuw 2013
79.2 24.9 108 79.7 27.6 101 −0.50 [−7.64, 6.64] Hollingworth 2013
12 months 80.26 26.65 268 82.44 24.7 300 −2.18 [−6.42, 2.06] Braeken 2013
81 27 80 85 25 80 −4.00 [−12.06, 4.06] de Leeuw 2013
80.5 26.4 106 84.1 21.9 103 −3.60 [−10.17, 2.97] Hollingworth 2013
14 months 78.8 29.57 235 78 28.25 239 0.80 [−4.41, 6.01] Bergholdt 2013
Role functioning (emotional) 4th follow‐up visit SF‐36 69 44 104 60 44 95 9.00 [−3.24, 21.24] Detmar 2002
66 N/A 108 68 N/A 110 N/E Hilarius 2008
Role functioning (physical) 36 42 104 31 41 95 5.00 [−6.54, 16.54] Detmar 2002
30 N/A 108 33 N/A 110 N/E Hilarius 2008
Emotional functioning 1 month EORTC QLQ‐C30 78.28 15.93 28 65.87 20.51 28 12.41 [2.79, 22.03] Bramsen 2008
79.1 21.1 109 77.8 21.4 103 1.30 [−4.42, 7.02] Hollingworth 2013
FACT‐C 21.2 2 20 19.4 3.7 21 1.80 [−0.01, 3.61] Young 2010
6 weeks EORTC QLQ‐C30 74.2 22.925 42 76.4 20.825 43 −2.20 [−11.52, 7.12] Nimako 2015
76.6 25 43 76.4 20.825 43 0.20 [−9.53, 9.93]
2 months 81.43 24.62 55 73.23 24.1 53 8.20 [−0.99, 17.39] Schofield 2013
3 months 78.38 22.75 268 79.46 20.68 300 −1.08 [−4.67, 2.51] Braeken 2013
75.31 26.7 55 75.51 25.26 53 −0.20 [−10.00, 9.60] Schofield 2013
FACT‐C 21.8 1.9 20 19.2 3.2 21 2.60 [1.00, 4.20] Young 2010
6 months EORTC QLQ‐C30 81.6 21.17 278 80.5 20.87 293 1.10 [−2.35, 4.55] Bergholdt 2013
84 19 80 85 19 80 −1.00 [−6.89, 4.89] de Leeuw 2013
81.2 18 108 80.3 20.7 101 0.90 [−4.37, 6.17] Hollingworth 2013
12 months 83.66 20.8 268 81.23 20.6 300 2.43 [−0.98, 5.84] Braeken 2013
82 23 80 85 18 80 −3.00 [−9.40, 3.40] de Leeuw 2013
78.7 21.6 106 80.3 21.4 103 −1.60 [−7.43, 4.23] Hollingworth 2013
14 months 80.8 21.93 238 80.7 22 240 0.10 [−3.84, 4.04] Bergholdt 2013
Cognitive functioning 1 month 85.12 19.43 28 75 25.46 28 10.12 [−1.74, 21.98] Bramsen 2008
79.8 20.5 109 78.2 21.8 103 1.60 [−4.10, 7.30] Hollingworth 2013
6 weeks 76.6 25 42 81.4 25 43 −4.80 [−15.43, 5.83] Nimako 2015
83.7 25 41 81.4 25 43 2.30 [−8.40, 13.00]
2 months 80.45 26.25 55 75.34 25.7 53 5.11 [−4.69, 14.91] Schofield 2013
3 months 83.92 19.73 268 84.27 19.49 300 −0.35 [−3.58, 2.88] Braeken 2013
80.4 27.51 55 77.73 26.21 53 2.67 [−7.46, 12.80] Schofield 2013
6 months 83.9 22.02 278 83 21.63 290 0.90 [−2.69, 4.49] Bergholdt 2013
88 17 80 87 17 80 1.00 [−4.27, 6.27] de Leeuw 2013
81 20.3 108 80.7 19.7 101 0.30 [−5.12, 5.72] Hollingworth 2013
12 months 82.46 22.11 268 82.82 19.98 300 −0.36 [−3.84, 3.12] Braeken 2013
87 20 80 86 21 80 1.00 [−5.35, 7.35] de Leeuw 2013
82.9 18.6 106 79.8 22.5 103 3.10 [−2.51, 8.71] Hollingworth 2013
14 months 85.1 23.49 238 82.6 23.04 245 2.50 [−1.65, 6.65] Bergholdt 2013
Social functioning 1 month 66.07 26.64 28 61.63 29.06 28 4.44 [−10.16, 19.04] Bramsen 2008
69 31.7 109 67.3 29.7 103 1.70 [−6.57, 9.97] Hollingworth 2013
FACT‐C 23.4 3.8 20 22.6 5.4 21 0.80 [−2.05, 3.65] Young 2010
6 weeks EORTC QLQ‐C30 73.8 25 42 75.8 25 42 −2.00 [−12.69, 8.69] Nimako 2015
75.8 25 44 75.8 25 42 0.00 [−10.57, 10.57]
2 months EORTC QLQ‐C30 68.28 31.96 55 70.58 31.16 53 −2.30 [−14.20, 9.60] Schofield 2013
3 months 83.46 23.57 268 81.81 22.37 300 1.65 [−2.14, 5.44] Braeken 2013
65.03 34.11 55 71.29 32.61 53 −6.26 [−18.84, 6.32] Schofield 2013
FLIC 11.6 2.4 60 11.4 2.3 60 0.20 [−0.64, 1.04] Rosenbloom 2007
11.2 2.4 60 11.4 2.3 60 −0.20 [−1.04, 0.64]
FACT‐C 24.1 3.7 20 22.8 4.4 21 1.30 [−1.18, 3.78] Young 2010
6 months EORTC QLQ‐C30 86 23.8 280 85.7 23.56 295 0.30 [−3.57, 4.17] Bergholdt 2013
91 15 80 90 16 80 1.00 [−3.81, 5.81] de Leeuw 2013
78.3 26.8 108 78.2 28.2 101 0.10 [−7.37, 7.57] Hollingworth 2013
FLIC 11.4 2.3 51 11.5 1.8 52 −0.10 [−0.90, 0.70] Rosenbloom 2007
11.1 2.3 51 11.5 1.8 52 −0.40 [−1.20, 0.40]
12 months EORTC QLQ‐C30 86.99 20.73 268 87.55 19.1 300 −0.56 [−3.85, 2.73] Braeken 2013
90 19 80 91 21 80 −1.00 [−7.21, 5.21] de Leeuw 2013
81.3 27.5 106 84 23.4 103 −2.70 [−9.62, 4.22] Hollingworth 2013
14 months 87.4 21.93 238 88.2 22.11 242 −0.80 [−4.74, 3.14] Bergholdt 2013
4th follow‐up visit SF‐36 65 30 104 63 29 95 2.00 [−6.20, 10.20] Detmar 2002
69 N/A 108 65 N/A 110 N/E Hilarius 2008
Fatigue 1 month EORTC QLQ‐C30 58.33 23.55 28 43.25 28.74 28 15.08 [1.32, 28.84] Bramsen 2008
3 months 66.93 26.64 268 67.06 25.18 300 −0.13 [−4.41, 4.15] Braeken 2013
6 months 65.8 28 279 62.6 26.92 292 3.20 [−1.31, 7.71] Bergholdt 2013
76 21 80 75 23 80 1.00 [−5.82, 7.82] de Leeuw 2013
12 months 74.07 24.15 268 76.29 22.63 300 −2.22 [−6.08, 1.64] Braeken 2013
81 25 80 78 24 80 3.00 [−4.59, 10.59] de Leeuw 2013
14 months 67.7 26.4 234 67.9 26.17 244 −0.20 [−4.91, 4.51] Bergholdt 2013
Nausea/vomiting 1 month 82.14 22.19 28 74.4 27.02 28 7.74 [−5.21, 20.69] Bramsen 2008
3 months 92.85 18.51 268 95.77 12.2 300 −2.92 [−5.53, −0.31] Braeken 2013
FLIC 11.6 2.7 60 11.4 2.7 60 0.20 [−0.77, 1.17] Rosenbloom 2007
11.5 2.7 60 11.4 2.7 60 0.10 [−0.87, 1.07]
6 months EORTC QLQ‐C30 92 17.12 284 91.9 17.6 300 0.10 [−2.72, 2.92] Bergholdt 2013
97 13 80 96 13 80 1.00 [−3.03, 5.03] de Leeuw 2013
FLIC 11.8 2.7 51 11.1 2.9 52 0.70 [−0.38, 1.78] Rosenbloom 2007
11.6 3 51 11.1 2.9 52 0.50 [−0.64, 1.64]
12 months EORTC QLQ‐C30 96.86 10.43 268 96.23 12.9 300 0.63 [−1.29, 2.55] Braeken 2013
97 13 80 96 10 80 1.00 [−2.59, 4.59] de Leeuw 2013
14 months 94.4 13.26 236 94.5 12.69 244 −0.10 [−2.42, 2.22] Bergholdt 2013
Pain 1 month 84.52 21.24 28 63.69 33.96 28 20.83 [5.99, 35.67] Bramsen 2008
3 months 82.09 25.44 268 81.34 23.49 300 0.75 [−3.29, 4.79] Braeken 2013
6 months 78 26.91 274 77 27.35 283 1.00 [−3.51, 5.51] Bergholdt 2013
85 22 80 86 23 80 −1.00 [−7.97, 5.97] de Leeuw 2013
EORTC QLQ‐H&N35 85 16 80 85 14 80 0.00 [−4.66, 4.66]
12 months EORTC QLQ‐C30 85.16 22.02 268 86.33 23.22 300 −1.17 [−4.89, 2.55] Braeken 2013
88 22 80 85 22 80 3.00 [−3.82, 9.82] de Leeuw 2013
EORTC QLQ‐H&N35 86 17 80 86 18 80 0.00 [−5.43, 5.43]
14 months EORTC QLQ‐C30 78.6 27.95 234 78.1 26.79 241 0.50 [−4.43, 5.43] Bergholdt 2013
4th follow‐up visit SF‐36 68 28 104 66 28 95 2.00 [−5.79, 9.79] Detmar 2002
74 N/A 108 75 N/A 110 N/E Hilarius 2008
Dyspnoea 1 month EORTC QLQ‐C30 82.14 21.24 28 77.78 22.65 28 4.36 [−7.14, 15.86] Bramsen 2008
3 months 82.41 25.44 268 81.44 27.52 300 0.97 [−3.39, 5.33] Braeken 2013
6 months 82.1 27.49 286 83 27.15 297 −0.90 [−5.34, 3.54] Bergholdt 2013
90 20 80 86 23 80 4.00 [−2.68, 10.68] de Leeuw 2013
12 months 85.9 20.73 268 84.95 24.97 300 0.95 [−2.81, 4.71] Braeken 2013
88 21 80 88 19 80 0.00 [−6.21, 6.21] de Leeuw 2013
14 months 84.6 27.12 233 86.8 25.43 245 −2.20 [−6.92, 2.52] Bergholdt 2013
Insomnia 1 month 88.1 18.62 28 69.05 29.99 28 19.05 [5.97, 32.13] Bramsen 2008
3 months 73.39 30.19 268 71.83 30.13 300 1.56 [−3.41, 6.53] Braeken 2013
6 months 72.7 31.73 285 72.5 30.91 302 0.20 [−4.87, 5.27] Bergholdt 2013
80 28 80 82 25 80 −2.00 [−10.23, 6.23] de Leeuw 2013
12 months 75.73 30.27 268 77.95 28.42 300 −2.22 [−7.07, 2.63] Braeken 2013
81 30 80 82 25 80 −1.00 [−9.56, 7.56] de Leeuw 2013
14 months 71.5 32.24 240 70.4 31.98 248 1.10 [−4.60, 6.80] Bergholdt 2013
Appetite loss 1 month 75 30.93 28 61.9 33.6 28 13.10 [−3.82, 30.02] Bramsen 2008
3 months 85.96 26 268 91.43 21.36 300 −5.47 [−9.41, −1.53] Braeken 2013
6 months 84.1 27.59 288 85.9 27.33 301 −1.80 [−6.24, 2.64] Bergholdt 2013
87 23 80 91 19 80 −4.00 [−10.54, 2.54] de Leeuw 2013
12 months 94.01 17.37 268 93.36 18.22 300 0.65 [−2.28, 3.58] Braeken 2013
93 17 80 92 21 80 1.00 [−4.92, 6.92] de Leeuw 2013
14 months 92.1 19.62 239 90.4 19.91 246 1.70 [−1.82, 5.22] Bergholdt 2013
Constipation 1 month 83.33 26.45 28 79.76 24.58 28 3.57 [−9.80, 16.94] Bramsen 2008
3 months 91.6 18.73 268 89.63 21.98 300 1.97 [−1.38, 5.32] Braeken 2013
6 months 88.7 25.68 284 87.4 25.48 299 1.30 [−2.85, 5.45] Bergholdt 2013
92 21 80 94 14 80 −2.00 [−7.53, 3.53] de Leeuw 2013
12 months 95.03 14.5 268 92.54 17.73 300 2.49 [−0.16, 5.14] Braeken 2013
93 18 80 94 15 80 −1.00 [−6.13, 4.13] de Leeuw 2013
14 months 91.1 23.39 236 88.1 23.19 248 3.00 [−1.15, 7.15] Bergholdt 2013
Diarrhoea 1 month 90.48 19.99 28 83.33 23.13 28 7.15 [−4.17, 18.47] Bramsen 2008
3 months 90.29 19.71 268 88.53 22.29 300 1.76 [−1.69, 5.21] Braeken 2013
6 months 88.6 22.26 284 88.7 21.97 299 −0.10 [−3.69, 3.49] Bergholdt 2013
95 15 80 94 16 80 1.00 [−3.81, 5.81] de Leeuw 2013
12 months 92.22 17.55 268 92.41 17.8 300 −0.19 [−3.10, 2.72] Braeken 2013
96 11 80 92 18 80 4.00 [−0.62, 8.62] de Leeuw 2013
14 months 90 23.49 238 88.6 23.28 250 1.40 [−2.75, 5.55] Bergholdt 2013
Financial difficulties 1 month 90.48 21.96 28 88.1 22.62 28 2.38 [−9.30, 14.06] Bramsen 2008
3 months 94.88 15.54 268 93.14 17.34 300 1.74 [−0.96, 4.44] Braeken 2013
6 months 92 19.69 284 92.4 19.27 297 −0.40 [−3.57, 2.77] Bergholdt 2013
93 17 80 92 20 80 1.00 [−4.75, 6.75] de Leeuw 2013
12 months 92.98 17.96 268 93.23 19.42 300 −0.25 [−3.32, 2.82] Braeken 2013
92 22 80 93 15 80 −1.00 [−6.83, 4.83] de Leeuw 2013
14 months 93.3 20.27 236 93.5 20.53 242 −0.20 [−3.86, 3.46] Bergholdt 2013
Swallowing 6 months EORTC QLQ‐H&N35 96 18 80 89 16 80 7.00 [1.72, 12.28] de Leeuw 2013
12 months 91 19 80 90 15 80 1.00 [−4.30, 6.30]
Senses 6 months 83 24 80 86 21 80 −3.00 [−9.99, 3.99]
12 months 82 26 80 85 23 80 −3.00 [−10.61, 4.61]
Speech 6 months 88 21 80 92 15 80 −4.00 [−9.66, 1.66]
12 months 89 19 80 90 19 80 −1.00 [−6.89, 4.89]
Social eating 6 months 85 18 80 91 19 80 −6.00 [−11.74, −0.26]
12 months 90 19 80 91 17 80 −1.00 [−6.59, 4.59]
Social contact 6 months 94 10 80 96 9 80 −2.00 [−4.95, 0.95]
12 months 95 12 80 97 8 80 −2.00 [−5.16, 1.16]
Less sexuality 6 months 81 26 80 80 29 80 1.00 [−7.53, 9.53]
12 months 81 27 80 85 23 80 −4.00 [−11.77, 3.77]
Teeth problems 6 months 85 28 80 83 27 80 2.00 [−6.52, 10.52]
12 months 89 24 80 88 24 80 1.00 [−6.44, 8.44]
Opening mouth 6 months 83 29 80 86 23 80 −3.00 [−11.11, 5.11]
12 months 89 21 80 90 21 80 −1.00 [−7.51, 5.51]
Dry mouth 6 months 59 33 80 62 35 80 −3.00 [−13.54, 7.54]
12 months 62 34 80 67 33 80 −5.00 [−15.38, 5.38]
Sticky saliva 6 months 66 32 80 77 32 80 −11.00 [−20.92, −1.08]
12 months 75 32 80 78 29 80 −3.00 [−12.46, 6.46]
Coughing 6 months 84 23 80 80 30 80 4.00 [−4.28, 12.28]
12 months 80 26 80 85 25 80 −5.00 [−12.90, 2.90]
Feeling ill 6 months 94 17 80 88 24 80 6.00 [−0.44, 12.44]
12 months 93 22 80 91 18 80 2.00 [−4.23, 8.23]
Use of painkillers 6 months 71 46 80 76 43 80 −5.00 [−18.80, 8.80]
12 months 78 42 80 78 42 80 0.00 [−13.02, 13.02]
Use of nutritional supplements 6 months 78 42 80 87 34 80 −9.00 [−20.84, 2.84]
12 months 91 28 80 92 27 80 −1.00 [−9.52, 7.52]
Use of feeding tube 6 months 97 18 80 100 0 80 N/E
12 months 97 18 80 97 12 80 0.00 [−4.74, 4.74]
Weight loss 6 months 84 37 80 83 38 80 1.00 [−10.62, 12.62]
12 months 85 36 80 87 33 80 −2.00 [−12.70, 8.70]
Weight gain 6 months 74 44 80 65 48 80 9.00 [−5.27, 23.27]
12 months 73 45 80 66 48 80 7.00 [−7.42, 21.42]
Vitality 4th follow‐up visit SF‐36 51 25 104 49 25 95 2.00 [−4.95, 8.95] Detmar 2002
56 N/A 108 51 N/A 110 N/E Hilarius 2008
Mental health 70 19 104 68 21 95 2.00 [−3.58, 7.58] Detmar 2002
72 N/A 108 72 N/A 110 N/E Hilarius 2008
Hardship 3 months FLIC 15.3 3.5 60 15.1 4.2 60 0.20 [−1.18, 1.58] Rosenbloom 2007
14.2 3.9 60 15.1 4.2 60 −0.90 [−2.35, 0.55]
6 months 15.2 4.1 51 14.6 3.8 52 0.60 [−0.93, 2.13]
15.4 3.6 51 14.6 3.8 52 0.80 [−0.63, 2.23]
Psychological well‐being 3 months 32.1 4.7 60 30.4 6.5 60 1.70 [−0.33, 3.73]
30.3 6.3 60 30.4 6.5 60 −0.10 [−2.39, 2.19]
6 months 30.6 5.9 60 29.7 6.1 60 0.90 [−1.25, 3.05]
30.1 6.9 60 29.7 6.1 60 0.40 [−1.93, 2.73]
Colorectal cancer symptom‐related well‐being 1 month FACT‐C 21.4 3.3 20 20.7 5.3 21 0.70 [−1.99, 3.39] Young 2010
3 months 22.8 3.7 20 19.8 4.1 21 3.00 [0.61, 5.39]
Distress (continuous) Tension/anxiety 1 month POMS 4.4 4.5 109 4.4 4.4 103 0.00 [−1.20, 1.20] Hollingworth 2013
3 months HADS 4.66 3.68 268 4.86 3.81 300 −0.20 [−0.82, 0.42] Braeken 2013
6 months POMS 4.1 4.3 108 4.1 4.4 101 0.00 [−1.18, 1.18] Hollingworth 2013
12 months HADS 4.57 3.90 268 4.98 4.24 300 −0.41 [−1.08, 0.26] Braeken 2013
POMS 4.1 4.2 106 3.7 4.4 103 0.40 [−0.77, 1.57] Hollingworth 2013
14 months 3.56 4.12 226 3.82 4.12 226 −0.26 [−1.02, 0.50] Bergholdt 2013
Depression/dejection 1 month 4.4 6.1 109 4 5.3 103 0.40 [−1.14, 1.94] Hollingworth 2013
3 months HADS 3.68 4.11 268 3.72 3.76 300 −0.04 [−0.69, 0.61] Braeken 2013
6 months POMS 3.7 5 108 3.8 5.4 101 −0.10 [−1.51, 1.31] Hollingworth 2013
12 months HADS 3.45 3.78 268 3.7 4.08 300 −0.25 [−0.90, 0.40] Braeken 2013
POMS 3.9 5.5 106 2.9 4.5 103 1.00 [−0.36, 2.36] Hollingworth 2013
14 months 3.26 4.99 229 3.85 4.93 223 −0.59 [−1.50, 0.32] Bergholdt 2013
Psychological distress (+ subscale) 1 month GHQ‐12 1.54 1.57 28 3.31 1.7 28 −1.77 [−2.63, −0.91] Bramsen 2008
Psychological distress (‐ subscale) 1.55 1.43 28 2.5 1.86 28 −0.95 [−1.82, −0.08]
Psychological distress (total score) At discharge from hospital HADS N/A N/A N/A N/A N/A N/A 0.9 [−0.1, 1.9] Singer 2017
1 month DT 3.09 2.8 28 5.81 3.29 28 −2.72 [−4.32, −1.12] Bramsen 2008
1.9 2.1 20 2.8 3 21 −0.90 [−2.48, 0.68] Young 2010
2.3 1.89 346 2.4 2.91 363 −0.10 [−0.46, 0.26] Young 2013
2 months 2.46 2.7 55 2.91 2.62 53 −0.45 [−1.45, 0.55] Schofield 2013
HADS 10.77 8.4 55 11.15 8.23 53 −0.38 [−3.52, 2.76]
3 months GHQ‐12 2.74 3.26 268 2.85 3.38 300 −0.11 [−0.66, 0.44] Braeken 2013
PSI 15 12.7 123 15.5 13.1 127 −0.50 [−3.70, 2.70] Maunsell 1996
DT 2.85 2.9 55 2.99 2.77 53 −0.14 [−1.21, 0.93] Schofield 2013
1.3 N/A 20 2.1 N/A 21 N/E Young 2010
2 1.86 336 2 2.86 351 0.00 [−0.36, 0.36] Young 2013
HADS 11.52 8.8 55 10.34 8.52 53 1.18 [−2.09, 4.45] Schofield 2013
N/A N/A N/A N/A N/A N/A 0.3 [−1.0, 1.6] Singer 2017
POMS (negative affect items) 6.6 6 60 8.5 9.3 60 −1.90 [−4.70, 0.90] Rosenbloom 2007
7.2 7.7 60 8.5 9.3 60 −1.30 [−4.36, 1.76]
6 months 8.1 8.5 51 8.3 8.2 52 −0.20 [−3.43, 3.03]
8.1 9.5 51 8.3 8.2 52 −0.20 [−3.63, 3.23]
DT 1.8 2.74 322 1.8 2.85 350 0.00 [−0.42, 0.42] Young 2013
HADS 9.5 8.2 341 9.4 7.2 234 0.10 [−1.17, 1.37] Singer 2017
12 months GHQ‐12 1.96 3.14 268 2.14 3.22 300 −0.18 [−0.70, 0.34] Braeken 2013
PSI 13.5 12.1 123 14.6 12.3 127 −1.10 [−4.12, 1.92] Maunsell 1996
Anger/hostility 1 month POMS 3 4.4 109 2.9 4 103 0.10 [−1.03, 1.23] Hollingworth 2013
6 months 2.8 3.7 108 2.6 3.3 101 0.20 [−0.75, 1.15]
12 months 3.5 5 106 2.5 3.7 103 1.00 [−0.19, 2.19]
14 months 1.88 3.46 230 2.03 3.33 223 −0.15 [−0.78, 0.48] Bergholdt 2013
Confusion/bewilderment 1 month 3.2 3.4 109 3.6 3.6 103 −0.40 [−1.34, 0.54] Hollingworth 2013
6 months 3.1 3.3 108 3.6 3.6 101 −0.50 [−1.44, 0.44]
12 months 3.1 3.3 106 3 3.2 103 0.10 [−0.78, 0.98]
14 months 2.11 3.24 231 2.45 3.15 229 −0.34 [−0.92, 0.24] Bergholdt 2013
Fatigue/inertia 1 month 7.2 6.4 109 7.8 6 103 −0.60 [−2.27, 1.07] Hollingworth 2013
6 months 6.6 5.4 108 6.7 5.8 101 −0.10 [−1.62, 1.42]
12 months 6.1 5.4 106 5.1 4.7 103 1.00 [−0.37, 2.37]
14 months 4.14 8.7 234 4.56 4.35 226 −0.42 [−1.67, 0.83] Bergholdt 2013
Vigour/activity 1 month 8.2 5.6 109 8.1 5.5 103 0.10 [−1.39, 1.59] Hollingworth 2013
6 months 3.1 3.3 108 3.6 3.6 101 −0.50 [−1.44, 0.44]
12 months 3.1 3.3 106 3 3.2 103 0.10 [−0.78, 0.98]
14 months 10.09 5.98 228 10.28 5.77 218 −0.19 [−1.28, 0.90] Bergholdt 2013
Total mood disturbance 1 month 38.09 23.5 109 38.6 21.99 103 −0.51 [−6.63, 5.61] Hollingworth 2013
6 months 34.46 20.87 108 34.87 22 101 −0.41 [−6.23, 5.41]
12 months 35.1 22.85 106 31.13 20.52 103 3.97 [−1.91, 9.85]
14 months 4.19 18.89 210 4.87 18.5 200 −0.68 [−4.30, 2.94] Bergholdt 2013
Psychosocial well‐being Emotional impact of the intervention (total) 1 month IES 15.77 14.53 28 25.91 12.49 28 −10.14 [−17.24, −3.04] Bramsen 2008
Emotional impact of the intervention (re‐experiencing) 8 8.04 28 12.5 6.61 28 −4.50 [−8.36, −0.64]
Emotional impact of the intervention (avoidance) 6.19 6.64 28 11.09 7.7 28 −4.90 [−8.67, −1.13]
Psychosocial adjustment (healthcare orientation) 6 months PAIS‐SR 51 8 80 49 9 80 2.00 [−0.64, 4.64] de Leeuw 2013
12 months 52 9 80 48 8 80 4.00 [1.36, 6.64]
Psychosocial adjustment (vocational environment) 6 months 57 7 80 56 7 80 1.00 [−1.17, 3.17]
12 months 54 7 80 54 7 80 0.00 [−2.17, 2.17]
Psychosocial adjustment (domestic environment) 6 months 43 9 80 42 9 80 1.00 [−1.79, 3.79]
12 months 42 9 80 41 9 80 1.00 [−1.79, 3.79]
Psychosocial adjustment (sexual relations) 6 months 46 8 80 47 9 80 −1.00 [−3.64, 1.64]
12 months 46 8 80 47 9 80 −1.00 [−3.64, 1.64]
Psychosocial adjustment (extended family relations) 6 months 49 7 80 52 8 80 −3.00 [−5.33, −0.67]
12 months 49 7 80 49 7 80 0.00 [−2.17, 2.17]
Psychosocial adjustment (social environment) 6 months 43 15 80 43 13 80 0.00 [−4.35, 4.35]
12 months 42 14 80 42 13 80 0.00 [−4.19, 4.19]
Psychosocial adjustment (psychological distress) 6 months 45 10 80 45 10 80 0.00 [−3.10, 3.10]
12 months 45 11 80 43 10 80 2.00 [−1.26, 5.26]
Psychosocial adjustment (total adjustment) 6 months 44 12 80 44 13 80 0.00 [−3.88, 3.88]
12 months 43 13 80 42 12 80 1.00 [−2.88, 4.88]
Physical functioning (number of arm problems reported) 3 months LES 1.6 1.3 122 1.6 1.4 126 0.00 [−0.34, 0.34] Maunsell 1996
12 months 1.3 1.4 122 1.1 1.4 126 0.20 [−0.15, 0.55]
Role functioning (household activities performed without help) 3 months 1.5 1.1 123 1.6 1.2 127 −0.10 [−0.39, 0.19]
12 months 2.1 1.2 123 2 1.3 127 0.10 [−0.21, 0.41]
Role functioning (hours worked per week) 3 months 22.1 15.1 123 22.4 14 127 −0.30 [−3.91, 3.31]
12 months 32.1 12.3 123 31.4 16.1 127 0.70 [−2.84, 4.24]
Social functioning (times per week engaged in social activities) 3 months 7.4 5.8 123 6.1 4.7 127 1.30 [−0.01, 2.61]
12 months 7.5 5.3 123 6.3 5 127 1.20 [−0.08, 2.48]
Social functioning (hours per day devoted to leisure activities) 3 months 4.5 3 123 4.3 2.4 127 0.20 [−0.47, 0.87]
12 months 4.1 2.6 123 4.5 3.1 127 −0.40 [−1.11, 0.31]
Social functioning (times per week engaged in physical activities/sports) 3 months 3 4.4 123 4.3 5.3 127 −1.30 [−2.51, −0.09]
12 months 3.7 4.6 123 3.6 4.2 127 0.10 [−0.99, 1.19]
Marital satisfaction 3 months LWMAT 46.6 21 76 50.5 25.3 82 −3.90 [−11.13, 3.33]
12 months 48.5 25.1 74 48.5 24.4 78 0.00 [−7.88, 7.88]
Supportive care needs General unmet need 1 month SCNS‐SF34 128.7 75.4 35 140.3 96.6 32 −11.60 [−53.36, 30.16] Harrison 2011
3 months 98.1 84.7 32 110 86.7 29 −11.90 [−54.99, 31.19]
59.9 57.85 336 56.8 76.07 351 3.10 [−6.98, 13.18] Young 2013
6 months 50 66.96 322 46.6 67.19 350 3.40 [−6.75, 13.55]
N/A N/A N/A N/A N/A N/A N/E Thewes 2009
CaSUN 10 13.1 30 14 18 30 −4.00 [−11.97, 3.97] Harrison 2011
Medical communication 2 months NA‐ALCP 2.37 1.3 55 2.21 1.24 53 0.16 [−0.32, 0.64] Schofield 2013
3 months 2.14 1.2 55 2.03 1.16 53 0.11 [−0.34, 0.56]
Psychological/emotional 1 month SCNS 16.6 11.2 20 19.6 20.4 21 −3.00 [−13.01, 7.01] Young 2010
2 months NA‐ALCP 2.04 0.9 55 1.94 0.87 53 0.10 [−0.23, 0.43] Schofield 2013
3 months 2.03 0.9 55 1.84 0.80 53 0.19 [−0.13, 0.51]
SCNS 8.2 8.1 20 17.7 18.7 21 −9.50 [−18.25, −0.75] Young 2010
6 months SCNS‐SF34 N/A N/A N/A N/A N/A N/A N/E Thewes 2009
Daily living 1 month SCNS 22.8 16.3 20 25.8 19 21 −3.00 [−13.82, 7.82] Young 2010
2 months NA‐ALCP 1.69 0.8 55 1.56 0.80 53 0.13 [−0.17, 0.43] Schofield 2013
3 months 1.75 0.9 55 1.57 0.87 53 0.18 [−0.15, 0.51]
SCNS 11.8 15.6 20 24.4 20.3 21 −12.60 [−23.65, −1.55] Young 2010
6 months SCNS‐SF34 N/A N/A N/A N/A N/A N/A N/E Thewes 2009
Financial 2 months NA‐ALCP 1.76 1.1 55 1.78 1.09 53 −0.02 [−0.43, 0.39] Schofield 2013
3 months 1.7 1.1 55 1.64 1.02 53 0.06 [−0.34, 0.46]
Symptoms 2 months 1.65 0.7 55 1.9 0.73 53 −0.25 [−0.52, 0.02]
3 months 1.67 0.8 55 1.86 0.73 53 −0.19 [−0.48, 0.10]
Social 2 months 1.49 0.7 55 1.43 0.66 53 0.06 [−0.20, 0.32]
3 months 1.54 0.7 55 1.38 0.73 53 0.16 [−0.11, 0.43]
Health system and information 1 month SCNS 22.6 10.3 20 23.1 18 21 −0.50 [−9.42, 8.42] Young 2010
3 months 19.4 10 20 4.8 7.7 21 14.60 [9.12, 20.08]
6 months SCNS‐SF34 N/A N/A N/A N/A N/A N/A N/E Thewes 2009
Patient care and support 1 month SCNS 18.5 7.4 20 14.4 14.9 21 4.10 [−3.05, 11.25] Young 2010
3 months 10.8 9.5 20 1.8 6.1 21 9.00 [4.09, 13.91]
6 months SCNS‐SF34 N/A N/A N/A N/A N/A N/A N/E Thewes 2009
Sexuality 1 month SCNS 7.9 11.9 20 8.8 22.9 21 −0.90 [−12.00, 10.20] Young 2010
3 months 5.7 17.8 20 3.9 9.4 21 1.80 [−6.98, 10.58]
6 months SCNS‐SF34 N/A N/A N/A N/A N/A N/A N/E Thewes 2009
Patient satisfaction Needs addressed After clinical visit PDIS 4.4 0.4 27 4.2 0.7 26 0.20 [−0.11, 0.51] Taenzer 2000
4th follow‐up visit PSQ‐C N/A N/A 104 N/A N/A 95 N/E Detmar 2002
N/A N/A 108 N/A N/A 110 N/E Hilarius 2008
Active involvement N/A N/A 104 N/A N/A 95 N/E Detmar 2002
N/A N/A 108 N/A N/A 110 N/E Hilarius 2008
Patient‐physician interaction After clinical visit PDIS 4.5 0.4 27 4.5 0.5 26 0.00 [−0.24, 0.24] Taenzer 2000
4th follow‐up visit PSQ‐C N/A N/A 104 N/A N/A 95 N/E Detmar 2002
N/A N/A 108 N/A N/A 110 N/E Hilarius 2008
Information received After clinical visit PDIS 4.4 0.5 27 4.5 0.6 26 −0.10 [−0.40, 0.20] Taenzer 2000
MOSPVRQ 3.65 0.67 147 3.81 0.45 130 −0.16 [−0.29, −0.03] Kutner 1999
4th follow‐up visit PSQ‐C N/A N/A 104 N/A N/A 95 N/E Detmar 2002
N/A N/A 108 N/A N/A 110 N/E Hilarius 2008
Support received 4.3 0.72 104 4 0.89 95 0.30 [0.07, 0.53] Detmar 2002
N/A N/A 108 N/A N/A 110 N/E Hilarius 2008
General satisfaction After clinical visit MOSPVRQ 3.63 0.68 149 3.76 0.52 133 −0.13 [−0.27, 0.01] Kutner 1999
3 months PSQ‐III general satisfacion 23.2 3.7 60 24.6 4.2 60 −1.40 [−2.82, 0.02] Rosenbloom 2007
23 4.1 60 24.6 4.2 60 −1.60 [−3.09, −0.11]
6 months 22.4 4.2 51 24.4 4.1 52 −2.00 [−3.60, −0.40]
23.1 4.2 51 24.4 4.1 52 −1.30 [−2.90, 0.30]
TPVCSQ 70.7 17.1 108 71.2 16.1 101 −0.50 [−5.00, 4.00] Hollingworth 2013
Communication satisfaction After clinical visit MOSPVRQ 3.82 0.53 149 3.87 0.36 133 −0.05 [−0.15, 0.05] Kutner 1999
3 months PSQ‐III communication satisfaction 21.2 2.8 60 21.4 2.3 60 −0.20 [−1.12, 0.72] Rosenbloom 2007
21.1 3 60 21.4 2.3 60 −0.30 [−1.26, 0.66]
6 months 21.2 2.8 51 20.8 3.2 52 0.40 [−0.76, 1.56]
21.2 3 51 20.8 3.2 52 0.40 [−0.80, 1.60]
Time spent with medical doctor satisfaction After clinical visit MOSPVRQ 3.53 0.78 149 3.7 0.59 133 −0.17 [−0.33, −0.01] Kutner 1999
Skills of the medical doctor satisfaction 3.78 0.54 149 3.85 0.40 133 −0.07 [−0.18, 0.04]
Abbreviations: CaSUN (Cancer Survivors’ Unmet Needs Measure); CI (confidence interval); DT (Distress Thermometer); EORTC QLQ‐C30 (European Organisation for Research and Treatment of Cancer‐Quality of Life Questionnaire‐Core 30); EORTC QLQ‐H&N35 (European Organisation for Research and Treatment of Cancer‐Quality of Life Questionnaire‐Head and Neck Cancer 35 items); EQ‐5D (EuroQol 5D); FACT‐C (Functional Assessment of Cancer Therapy‐Colorectal); FLIC (Functional Living Index‐Cancer); GHQ‐12 (General Health Questionnaire 12‐item version); HADS (Hospital Anxiety and Depression Scale); HRQoL (health‐related quality of life); IES (Impact of Events Scale); LES (Life Experiences Survey); LWMAT (Locke‐Wallace Marital Adjustment Scale); MD (mean difference); MOSPVRQ (Medical Outcomes Study Patient Visit Rating Questionnaire); NA‐ALCP (Needs Assessment for Advanced Lung Cancer Patients); POMS (Profile of Mood States); PAIS‐SR (Psychosocial Adjustment to Illness Scale – Self Reported); PDIS (Patient‐Doctor Interaction Scale); PSI (Psychiatric Symptom Index); PSQ‐III (Patient Satisfaction Questionnaire III); PSQ‐C (Patient Satisfaction Questionnaire Core); SCNS (Supportive Care Needs Survey); SCNS‐SF34 (Supportive Care Needs Survey‐Short Form); SD (standard deviation); SF‐36 (36‐item Short Form Health Survey); TPVCSQ (Trent Patient Views of Cancer Services Questionnaire); N/A: Not available; N/E: Not estimable.