Fig. 2. miR-145 mimic promotes VSMC proliferation and inhibits VSMC apoptosis. (A) miR-145 expression was increased in VSMCs transfected with miR-145 mimic or decreased with miR-145 inhibitor. (B) VSMC viability increased after treating with miR-145 mimic or decreased after treating with miR-145 inhibitor. (C and D) Caspase-8 expression was inhibited by miR-145 mimic and promoted by miR-145 inhibitor in VSMCs according to Western blot and qRT-PCR. ^*p<0.05, ^†p<0.01. VSMC, vascular smooth muscle cell.