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. 2019 Mar 19;60(4):352–359. doi: 10.3349/ymj.2019.60.4.352

Fig. 3. CTGF is a target of miR-145 in VSMCs. (A) miR-145 was bound to the 3′UTR of CTGF. (B) The luciferase activity of CTGF was decreased by miR-145 mimic in WT. (C) Western blot analysis showed higher expression of CTGF protein in AAD specimens than in NAD specimens. (D) qRT-PCR showed a higher expression of CTGF mRNA in AAD specimens than in NAD specimens. (E) Regression analysis showed a negative correlation of miR-145 with CTGF expression. (F) Western blot showed decreased or increased expression of CTGF protein in the miR-145 mimic or miR-145 inhibitor group, respectively. (G) qRT-PCR showed decreased or increased expression of CTGF gene in the miR-145 mimic or miR-145 inhibitor group, respectively. *p<0.05, p<0.01. CTGF, connective tissue growth factor; VSMC, vascular smooth muscle cell; AAD, acute aortic dissection; NAD, normal aortic dissection.

Fig. 3