12.

Classification of gastrointestinal adverse events of targeted therapy for RCC

Severity*	Diarrhea	Nausea	Vomiting
RCC, renal cell cancer; *, The grading standard adopts the National Cancer Institute General Terminology Standard for Adverse Events (NCI-CTCAE 4.0)
Grade I	Compared with baseline, the number of bowel movements increased by <4 times per day	Loss of appetite, no change in eating habits	Vomiting occurs 1−2 times within 24 h with 5-min interval
Grade II	Compared with baseline, the number of bowel movements increased by 4−6 times per day, intravenous fluid administration <24 h	Reduced oral food intake, no significant weight loss, dehydration or malnutrition	Vomiting occurs 3−5 times within 24 h with 5-min interval
Grade III	Compared with baseline, the number of bowel movements increased by 7 times per day, encopresis, and hospitalization might be necessary, personal life was affected.	Insufficient oral intake of energy and water, nasal feeding, parenteral nutrition or hospitalization might be necessary	Vomiting occurs >6 times within 24 h with 5-min interval. Nasal feeding, parenteral nutrition or hospitalization might be necessary
Grade IV	Life threatening, urgent treatment is needed	−	Life threatening, urgent treatment is needed
Grade V	Death	−	Death