13.

Hypothyroidism grading system of targeted therapy for RCC

Severity*	Clinical characteristics
RCC, renal cell cancer; *, The grading standard adopts the National Cancer Institute General Terminology Standard for Adverse Events (NCI-CTCAE 4.0)
Grade I	Asymptomatic; only observed by examination or diagnostic examination; no need of treatment
Grade II	Symptomatic; affecting daily activity; thyroid hormone replacement therapy is required.
Grade III	Severe symptoms; affecting daily activity; hospitalization is required
Grade IV	Life threatening; urgent treatment is needed
Grade V	Death