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WHO/ISUP urological pathology grading system for RCC and papillary RCC
| Grade | Definition |
| I | Nucleoli are absent or inconspicuous and basophilic at ×400 magnification |
| II | Nucleoli are inconspicuous and eosinophilic at ×400 magnification and visible but not prominent at ×100 magnification |
| III | Nucleoli are conspicuous and eosinophilic at ×100 magnification |
| IV | There is extreme nuclear pleophorphism, multinucleate giant cells, and/or rhabdoid and/or sarcomatoid differentiation. |
