9.

Classification of hypertension related to targeted therapy for RCC

Severity grading*	Clinical characteristics
RCC, renal cell cancer; *, The grading standard adopts the America National Cancer Institute General Terminology Standard for Adverse Events (NCI-CTCAE 4.0); 1 mmHg=0.133 kPa
Grade I	Prehypertension stage (systolic pressure 120−139 mmHg, or diastolic pressure 80−89 mmHg)
Grade II	Stage I hypertension (systolic pressure140−1S9 mmHg, or diastolic pressure 90−99 mmHg); Medical intervention is needed. Recurrent or persistent (>24 h) hypertension with symptomatic diastolic pressure increase >20 mmHg, or blood pressure 140/90 mmHg (normal pressure in the past), monotherapy is needed
Grade III	Stage II hypertension (systolic pressure ≥160 mmHg, diastolic pressure ≥100 mmHg); multi-drug therapy is needed.
Grade IV	Life-threatening hypertension (such as hypertension crisis) requires urgent treatment
Grade V	Death