2.

Univariable analysis and Cox proportional hazards regression analysis for all patients

Variables	Number	Univariable analysis		Multivariable analysis
		P		HR (95% CI)	P	β
M, male; F, female; PS, performance status; CEA, baseline carcinoembryonic antigen; CA19-9, baseline carbohydrate antigen 19-9; T4b, tumor invading the organs nearby; ORR, objective response rate; HR, hazard ratio; 95% CI, 95% confidence interval; β, β regression coefficients.
Age (years)		0.168
≥65	15
<65	80
Sex ratio (M:F)	67:28	0.016
PS		0.018
≥2	8
<2	87
Tumor size (cm)		0.050
≥7	36
<7	50
Tumor location		0.017
Cardia	36
Noncardia	59
Tumor differentiation		0.001
Poorly differentiated	74
Moderately/well-differentiated	21
CEA (ng/mL)		0.741
≥5	39
<5	46
CA19-9 (U/mL)		0.018
≥35	38
<35	45
Peritoneal seeding		0.013			0.050	0.297
Yes	27			1.35 (1.00−1.82)
No	68			Reference
T4b		0.280
Yes	17
No	78
Ascites		<0.001			<0.001	0.505
Yes	17			1.66 (1.25−2.21)
No	78			Reference
No. of noncurative factors		<0.001			<0.001	0.952
1	48			Reference
≥2	47			2.59 (1.77−3.80)
Chemotherapy response					<0.001	0.421
ORR	61	<0.001		Reference
Without ORR	34			1.52 (1.19−1.95)