5.

Multivariate Cox regression of risk factors associated with PFS

Covariables	Beta	SE	Wald	HR	95% CI	P
PFS, progression-free survival; LGG, low-grade glioma; HGG, high-grade glioma; IDH, isocitrate dehydrogenase; KPS, Karnofsky performance scale; EGFRvIII, epidermal growth factor receptor variant III; SE, standard error; HR, hazard ratio; 95% CI, 95% confidence interval.
Chart 1
Age (<50vs. ≥50 years)	0.619	0.226	7.502	1.857	1.192−2.892	0.006
Tumor grade (LGG vs. HGG)	1.605	0.337	22.744	4.977	2.574−9.625	<0.001
1p/19q codeletion (No vs. Yes)	−0.752	0.318	5.578	0.471	0.253−0.880	0.018
IDH mutation (No vs. Yes)	−0.744	0.256	8.449	0.475	0.288−0.785	0.004
KPS (≤80 vs. >80)	−0.668	0.205	10.668	0.513	0.343−0.766	0.001
EGFRvIII expression (Low vs. High)	−0.014	0.214	0.005	0.986	0.648−1.499	0.947
Chart 2
Age (<50vs. ≥50 years)	0.564	0.221	6.496	1.758	1.139−2.712	0.011
Tumor grade (LGG vs.HGG)	1.577	0.334	22.324	4.839	2.516−9.038	<0.001
1p/19q codeletion (No vs. Yes)	−0.854	0.318	7.211	0.426	0.228−0.794	0.007
IDH mutation (No vs. Yes)	−0.667	0.253	6.95	0.513	0.312−0.843	0.008
KPS (≤80 vs. >80)	−0.646	0.204	10.036	0.524	0.351−0.782	0.002
EGFRvIII nuclear translocation (<7%vs. ≥7%)	0.507	0.203	6.259	1.661	1.116−2.471	0.012