6.

Multivariate Cox regression of risk factors associated with OS

Covariables	Beta	SE	Wald	HR	95% CI	P
OS, overall survival; LGG, low-grade glioma; HGG, high-grade glioma; IDH, isocitrate dehydrogenase; EGFRvIII, epidermal growth factor receptor variant III; SE, standard error; HR, hazard ratio; 95% CI, 95% confidence interval.
Chart 1
Age (<50vs. ≥50 years)	0.687	0.25	7.544	1.988	1.217−3.245	0.006
Tumor grade (LGG vs. HGG)	2.154	0.48	20.112	8.617	3.362−22.087	<0.001
1p/19q codeletion (No vs. Yes)	−0.758	0.37	4.19	0.468	0.277−0.968	0.041
IDH mutation (No vs. Yes)	−0.673	0.28	5.777	0.51	0.295−0.883	0.016
EGFRvIII expression (Low vs. High)	−0.089	0.241	0.138	0.914	0.570−1.467	0.711
Chart 2
Age (<50vs. ≥50 years)	0.55	0.242	5.179	1.733	1.079−2.781	0.023
Tumor grade (LGG vs. HGG)	2.076	0.477	18.901	7.972	3.127−20.324	<0.001
1p/19q codeletion (No vs. Yes)	−0.861	0.37	5.421	0.423	0.205−0.873	0.020
IDH mutation (No vs. Yes)	−0.553	0.278	3.973	0.575	0.334−0.991	0.046
EGFRvIII nuclear translocation (<7%vs. ≥7%)	0.653	0.228	8.191	1.920	1.228−3.003	0.004