1.

Clinical tumor node metastasis (TNM) classification of prostate cancer

Category	Definition
*, invasion into the prostatic apex or into (but not beyond) the prostatic capsule is not classified as T3, but as T2; 1, metastasis no larger than 0.2 cm can be designated pNmi; 2, when more than one site of metastasis is present, the most advanced category is used. (p)M1c is the most advanced category.
T — Primary
Tx	Primary tumor cannot be assessed
T0	No evidence of primary tumor
T1	Clinically inapparent tumor that is not palpable
T1a	Tumor incidental histological finding in 5% or less of tissue resected
T1b	Tumor incidental histological finding in more than 5% of tissue resected
T1c	Tumor identified by needle biopsy [e.g. because of elevated prostate-specific antigen (PSA)]
T2	Tumor that is palpable and confined within the prostate
T2a	Tumor involves one half of one lobe or less
T2b	Tumor involves more than half of one lobe, but not both lobes
T2c	Tumor involves both lobes
T3	Tumor extends through the prostatic capsule*
T3a	Extracapsular extension (unilateral or bilateral) including microscopic bladder neck involvement
T3b	Tumor invades seminal vesicle(s)
T4	Tumor is fixed or invades adjacent structures other than seminal vesicles: external sphincter, rectum, levator muscles, and/or pelvic wall
N — Regional lymph nodes1
Nx	Regional lymph nodes cannot be assessed
N0	No regional lymph node metastasis
N1	Regional lymph node metastasis
M — Distant metastasis2
M0	No distant metastasis
M1	Distant metastasis
M1a	Non-regional lymph node(s)
M1b	Bone(s)
M1c	Other site(s)