1.
Demographic and baseline clinical characteristics of patients with N-DLBCL and EN-DLBCL
| Characteristics | n (%) | P | ||
| All patients | N-DLBCL | EN-DLBCL | ||
| Total | 1,085 | 679 (62.6) | 406 (37.4) | |
| Gender | 0.751 | |||
| Male | 608 (56.0) | 383 (56.4) | 225 (55.4) | |
| Female | 477 (44.0) | 296 (43.6) | 181 (44.6) | |
| Age (year) | 0.035 | |||
| ≤60 | 716 (66.0) | 464 (68.3) | 252 (62.1) | |
| >60 | 369 (34.0) | 215 (31.7) | 154 (37.9) | |
| Number of extranodal sites | 0.002 | |||
| 0 or 1 | 837 (77.1) | 545 (80.3) | 292 (71.9) | |
| ≥2 | 248 (22.9) | 134 (19.7) | 114 (28.1) | |
| Ann Arbor stage | <0.001 | |||
| I | 268 (24.7) | 125 (18.4) | 143 (35.2) | |
| II | 435 (40.1) | 293 (43.2) | 142 (35.0) | |
| III | 166 (15.3) | 139 (20.5) | 27 (6.7) | |
| IV | 216 (19.9) | 122 (18.0) | 94 (23.1) | |
| B symptoms | 0.021 | |||
| Presence | 204 (18.8) | 142 (20.9) | 62 (15.3) | |
| Absence | 881 (81.2) | 537 (79.1) | 344 (84.7) | |
| Bone marrow involvement | 0.012 | |||
| Presence | 79 (7.3) | 39 (5.7) | 40 (9.9) | |
| Absence | 1,006 (92.7) | 640 (94.3) | 366 (90.1) | |
| Bulky disease | <0.001 | |||
| Presence | 100 (9.2) | 83 (12.2) | 17 (4.2) | |
| Absence | 985 (90.8) | 596 (87.8) | 389 (95.8) | |
| ECOG performance status | 0.129 | |||
| 0 or 1 | 883 (81.4) | 562 (82.8) | 321 (79.1) | |
| ≥2 | 202 (18.6) | 117 (17.2) | 85 (20.9) | |
| Pathological classification | 0.062 | |||
| GCB | 302 (27.8) | 185 (27.2) | 117 (28.8) | |
| Non-GCB | 765 (70.5) | 478 (70.4) | 287 (70.7) | |
| Other | 18 (1.7) | 16 (2.4) | 2 (0.5) | |
| Ki-67 index (%) | 0.027 | |||
| ≤90 | 857 (79.0) | 552 (81.3) | 305 (75.1) | |
| >90 | 194 (17.9) | 105 (15.5) | 89 (21.9) | |
| Unknown | 34 (3.1) | 22 (3.2) | 12 (3.0) | |
| LDH | 0.001 | |||
| Normal | 595 (54.8) | 345 (50.8) | 250 (61.6) | |
| 1−2 fold | 365 (33.6) | 242 (35.6) | 123 (30.3) | |
| >2 fold | 125 (11.5) | 92 (13.5) | 33 (8.1) | |
| IPI score | 0.157 | |||
| 0 | 268 (24.7) | 158 (23.3) | 110 (27.1) | |
| Table 1 (continued) | ||||