Table 1.
Demographics, clinical, imaging and laboratory characteristics of the study cohort.
| Variables | CN (N=26) | MCI (N=36) | Total (N=62) | Differences CN vs. MCI (p-value) |
|---|---|---|---|---|
| Age mean ± sd | 76.81 ± 6.14 | 73.47 ± 7.98 | 74.87 ± 7.40 | 0.080 |
| Male sex n (%) | 9 (34.6) | 19 (52.8) | 28 (45.2) | 0.156 |
| Education mean ± sd | 17.08 ± 2.18 | 16.83 ± 3.67 | 16.94 ± 3.12 | 0.764 |
| mFRS mean ± sd | 17.58 ± 2.8 | 16.56 ± 3.1 | 17 ± 3 | 0.189 |
| Hypertension n (%) | 7 (26.9) | 27 (75.0) | 34 (54.8) | 0.001‡ |
| SBP mean ± sd | 135.77 ± 10.77 | 138.47 ± 16.47 | 137.34 ± 14.32 | 0.468 |
| DBP mean ± sd | 74.19 ± 9.70 | 73.89 ± 11.42 | 74.02 ± 10.65 | 0.913 |
| Hyperlipidemia n (%) | 2 (7.7) | 25 (73.5) | 27 (43.5) | 0.000‡ |
| Diabetes n (%) | 4 (15.4) | 10 (27.8) | 14 (22.6) | 0.247 |
| Smoking n (%) | 2 (7.7) | 1 (2.7) | 3 (4.8) | 0.567 |
| NAWM-FA mean ± sd | 0.59 ± 0.41 | 0.59 ± 0.55 | 0.59 ± 0.05 | 0.987 |
| Aβ1–42 mean ± sd | 320 ± 93.14 | 251.03 ± 90.82 | 279.95 ± 97.29 | 0.005¥ |
| WMH volume cc mean ± sd | 8.22 ± 9.98 | 13.30 ± 20.03 | 11.17 ± 16.65 | 0.238 |
CN = cognitively normal; MCI = mild cognitive impairment; mFRS = modified Framingham stroke risk score; SBP = systolic blood pressure; DBP = diastolic blood pressure; HLD = hyperlipidemia; NAWM-FA = fractional anisotropy values of the normally appearing white matter; Aβ1–42 = Cerebrospinal fluid amyloid beta 1–42 levels; WMH = white matter hyperintensities.
‡
Pearson Chi-square
¥
T test (2 sided)