Table 2. Approved Drugs for PAH and CTEPH.

Mechanism of Action	Drug Name	Indication	Route
Endothelin-receptor antagonists	Bosentan	PAH	Oral
	Ambrisentan	PAH	Oral
	Macitentan	PAH	Oral
Phosphodiesterase type 5 inhibitors	Sildenafil	PAH	Oral
	Tadalafil	PAH	Oral
Guanylate cyclase stimulators	Riociguat	PAH	Oral
		CTEPH
Prostacyclin analogues	Epoprostenol	PAH	Intravenous
	Iloprost	PAH	Inhaled
	Treprostinil	PAH	Subcutaneous
			Intravenous
	Beraprost	PAH	Oral
Prostaglandin I2 receptor agonists	Selexipag	PAH	Oral

CTEPH = chronic thromboembolic pulmonary hypertension; PAH = pulmonary arterial hypertension