Figure 6.

Proposed model for ABC‐dependent increase of platelet reactivity. The active metabolites of ABC and TAF/TDF are guanosine and adenosine analogues respectively. Left panel depicts the basic interaction between the endothelium and platelets in the presence of TAF/TDF. In this context, NO derived from the endothelium stimulates cGMP production in the platelet, leading to inhibition of aggregation. ABC/CBV‐TP may also directly enhance platelet granule release in a cGMP‐independent manner. Right panel depicts the proposed effect of CBV‐TP disrupting cGMP production, amplifying granule release and thrombus formation. eNOS: endothelial NOS; sGC: soluble GC