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. 2019 Mar 18;176(7):919–937. doi: 10.1111/bph.14594

Figure 5.

Figure 5

Dioscin adjusted TIGAR‐mediated apoptosis, autophagy, and DNA damage. (a) Effects of dioscin on the expression levels of p53, Bax, Bcl‐2, cleaved PAPR, and cleaved caspase‐3/9 in vitro and in vivo. (b) Effects of dioscin on the expression levels of p‐Akt/Akt, p‐mTOR/mTOR, Beclin‐1, and LC3 in vitro and in vivo. (c) Effects of dioscin on the expression levels of CDK5 and p‐ATM/ATM in vitro and in vivo. Total proteins from SMMC7721 and HepG2 cells, livers of rats, and tumour tissues of nude mice were isolated using the kit. After separation on SDS‐PAGE gels, the proteins were detected and imaged. Intensity values of the relative protein levels were normalized to GAPDH