Table 1.
The differentially up‐regulated proteins in SMMC7721 cells caused by dioscin
| Protein name | Gene symbol | Fold change |
|---|---|---|
| Hydroxymethylglutaryl‐CoA synthase, cytoplasmic | HMGCS1 | 4.467876 |
| Acyl carrier protein, mitochondrial | NDUFAB1 | 4.270876 |
| Squalene synthase | FDFT1 | 4.137811 |
| Keratin, type I cytoskeletal 10 | KRT10 | 4.08447 |
| Isopentenyl‐diphosphate 𝛿‐isomerase 1 | IDI1 | 2.954908 |
| LDL receptor (fragment) | LDLR | 2.897039 |
| Keratin, type II cytoskeletal 1 | KRT1 | 2.742402 |
| Complement decay‐accelerating factor | CD55l | 2.63388 |
| Fatty acid‐binding protein, heart (fragment) | FABP3 | 2.547575 |
| Lanosterol 14‐α demethylase | CYP51A1 | 2.493801 |
| Keratin, type II cytoskeletal 2 epidermal | KRT2 | 2.481374 |
| 14‐3‐3 protein σ | SFN | 2.449948 |
| SOD | SOD2 | 2.370577 |
| Signal peptidase complex subunit 2 | SPCS2 | 2.313942 |
| Long‐chain‐fatty‐acid‐CoA ligase 4 | ACSL4 | 2.309261 |
| 𝛿(24)‐sterol reductase | DHCR24 | 2.303789 |
| 7‐dehydrocholesterol reductase | DHCR7 | 2.237158 |
| Annexin A1 | ANXA1 | 2.218028 |
| Protein S100‐P | S100P | 2.205782 |
| ATPase inhibitor, mitochondrial | ATPIF1 | 2.17796 |
| Microsomal GSH S‐transferase 3 | MGST3 | 2.152152 |
| Forkhead box protein K1 | FOXK1 | 2.03466 |
| PG G/H synthase 2 | PTGS2 | 1.977949 |
| Myristoylated alanine‐rich C‐kinase substrate | MARCKS | 1.94862 |
| Gamma‐IFN‐inducible protein 16 | IFI16 | 1.941166 |
| Peroxiredoxin‐5, mitochondrial | PRDX5 | 1.936759 |
| Enoyl‐CoA hydratase, mitochondrial | ECHS1 | 1.933657 |
| Proprotein convertase subtilisin/kexin type 9 | PCSK9 | 1.932362 |
| Protein TBRG4 | TBRG4 | 1.92955 |
| OCIA domain‐containing protein 2 | OCIAD2 | 1.923373 |
| RNA exonuclease 4 | REXO4 | 1.921324 |
| Ras‐related GTP‐binding protein C | RRAGC | 1.918965 |
| Ras‐related protein Rab‐5B | RAB5B | 1.894384 |
| Translocator protein | TSPO | 1.887573 |
| CD97 antigen | CD97 | 1.884349 |
| Niemann‐Pick C1 protein | NPC1 | 1.855988 |
| Prelamin‐A/C | LMNA | 1.846607 |
| Integrin α‐2 | ITGA2 | 1.845733 |
| Cytochrome c oxidase subunit 7C, mitochondrial | COX7C | 1.84376 |
| Farnesyl pyrophosphate synthase | FDPS | 1.83849 |
| V‐type proton ATPase subunit d 1 | ATP6V0D1 | 1.835165 |
| Proliferation‐associated protein 2G4 | PA2G4 | 1.826637 |
| Translation machinery‐associated protein 7 | TMA7 | 1.81405 |
| Endoplasmin | HSP90B1 | 1.808616 |
| Mitochondrial carrier homolog 2 | MTCH2 | 1.790893 |
| Urokinase plasminogen activator surface receptor | PLAUR | 1.789592 |
| 3‐ketoacyl‐CoA thiolase, mitochondrial | ACAA2 | 1.781226 |
| Heterogeneous nuclear ribonucleoprotein F | HNRNPF | 1.780622 |
| High mobility group protein B3 (fragment) | HMGB3 | 1.773229 |
| Dual specificity tyrosine‐phosphorylation‐regulated kinase 1A | DYRK1A | 1.768352 |
| Vimentin | VIM | 1.762179 |
| Acyl‐CoA‐binding protein | DBI | 1.734179 |
| Ceramide synthase 2 | CERS2 | 1.730889 |
| ORM1‐like protein 2 | ORMDL2 | 1.722456 |
| Disks large‐associated protein 4 | DLGAP4 | 1.721456 |
| Protein S100‐A13 | S100A13 | 1.717785 |
| Basic leucine zipper and W2 domain‐containing protein 1 | BZW1 | 1.712186 |
| Insulin‐like growth factor‐binding protein 1 | IGFBP1 | 1.710111 |
| Perilipin‐3 | PLIN3 | 1.696373 |
| Voltage‐dependent anion‐selective channel protein 3 | VDAC3 | 1.682508 |
| Nicalin | NCLN | 1.665872 |
| NADH dehydrogenase (Ubiquinone) flavoprotein 1, 51 kDa, isoform CRA_c | NDUFV1 | 1.657116 |
| Myeloid‐derived growth factor | MYDGF | 1.653477 |
| Integrin α‐5 | ITGA5 | 1.651647 |
| Plectin | PLEC | 1.649441 |
| Isoleucine–tRNA ligase, mitochondrial | IARS2 | 1.637101 |
| Cytochrome c oxidase subunit 6C | COX6C | 1.631336 |
| ATP synthase F(0) complex subunit B1, mitochondrial | ATP5F1 | 1.627885 |
| Cytochrome c1, haem protein, mitochondrial | CYC1 | 1.620842 |
| Transformer‐2 protein homolog α | TRA2A | 1.610992 |
| 28S ribosomal protein S35, mitochondrial | MRPS35 | 1.607127 |
| Sorting nexin‐9 | SNX9 | 1.605466 |
| Lamin‐B1 | LMNB1 | 1.605438 |
| Reticulon‐3 | RTN3 | 1.605057 |
| Dolichyl‐diphosphooligosaccharide‐protein glycosyltransferase subunit 1 | RPN1 | 1.599851 |
| Protein FAM3C | FAM3C | 1.585922 |
| Transcription factor MafK | MAFK | 1.580469 |
| Alcohol dehydrogenase class‐3 | ADH5 | 1.579261 |
| PG E synthase | PTGES | 1.578501 |
| Minor histocompatibility antigen H13 | HM13 | 1.577779 |
| Cytochrome c oxidase copper chaperone | COX17 | 1.573968 |
| Soluble calcium‐activated nucleotidase 1 | CANT1 | 1.570252 |
| NADH dehydrogenase [ubiquinone] iron–sulfur protein 3, mitochondrial | NDUFS3 | 1.569836 |
| Obg‐like ATPase 1 | OLA1 | 1.569714 |
| Thiosulfate sulfur transferase | TST | 1.56659 |
| Acidic leucine‐rich nuclear phosphoprotein 32 family member A | ANP32A | 1.566353 |
| Acetyl‐CoA acetyltransferase, mitochondrial | ACAT1 | 1.564878 |
| Purine nucleoside phosphorylase | PNP | 1.563292 |
| Prefoldin subunit 3 | VBP1 | 1.562049 |
| Prohibitin‐2 | PHB2 | 1.560065 |
| Actin‐related protein 2/3 complex subunit 5 | ARPC5 | 1.559988 |
| ATP‐dependent RNA helicase DDX3X | DDX3X | 1.553437 |
| Calpain small subunit 1 | CAPNS1 | 1.549143 |
| Sulfide:quinone oxidoreductase, mitochondrial | SQRDL | 1.548049 |
| Amyloid β A4 protein | APP | 1.543608 |
| Kinesin light chain 2 | KLC2 | 1.543524 |
| Barrier‐to‐autointegration factor | BANF1 | 1.538895 |
| Lanosterol synthase | LSS | 1.537363 |
| Mitochondrial import receptor subunit TOM5 homolog | TOMM5 | 1.536781 |
| SWI/SNF complex subunit SMARCC2S | MARCC2 | 1.534996 |
| Hydroxyacyl‐CoA dehydrogenase, mitochondrial | HADH | 1.531318 |
| Syntenin‐1 | SDCBP | 1.527044 |
| Acidic leucine‐rich nuclear phosphoprotein 32 family member E | ANP32E | 1.520728 |
| E3 ubiquitin‐protein ligase RNF149 | RNF149 | 1.515388 |
| ATP synthase subunit O, mitochondrial | ATP5O | 1.515363 |
| Metal transporter CNNM2 | CNNM2 | 1.514863 |
| Ubiquitin‐40S ribosomal protein S27a | RPS27A | 1.514685 |
| Serine palmitoyltransferase 1 | SPTLC1 | 1.513388 |
| Carbamoyl‐phosphate synthase [ammonia], mitochondrial | CPS1‐ | 1.512657 |
| Integrin β‐1 | ITGB1 | 1.512505 |
| Uroporphyrinogen decarboxylase | UROD | 1.512451 |
| All‐trans‐retinol 13,14‐reductase | RETSAT | 1.512367 |
| Keratin, type II cytoskeletal 5 | KRT5 | 1.510872 |
| NADPH–cytochrome P450 reductase | POR | 1.505179 |
| Beta‐2‐microglobulin | B2M | 1.504594 |
| Vacuolar protein sorting‐associated protein 35 | VPS35 | 1.503595 |