Table 2.
The differentially down‐regulated proteins in SMMC7721 cells caused by dioscin
| Protein name | Gene symbol | Fold change |
|---|---|---|
| Plakophilin‐3 | PKP3 | 0.667412 |
| Ribosomal biogenesis protein LAS1L | LAS1L | 0.666549 |
| Ras GTPase‐activating‐like protein IQGAP2 | IQGAP2 | 0.666464 |
| Alkaline phosphatase, placental‐like | ALPPL2 | 0.66389 |
| 40S ribosomal protein S28 | RPS28 | 0.663475 |
| Protein arginine N‐methyltransferase 7 | PRMT7 | 0.659268 |
| OTU domain‐containing protein 7B | OTUD7B | 0.658997 |
| Fructose‐2,6‐bisphosphatase | TIGAR | 0.657632 |
| Brain‐specific angiogenesis inhibitor 1‐associated protein 2 | BAIAP2 | 0.656172 |
| DNA‐directed RNA polymerase I subunit RPA34 | CD3EAP | 0.653801 |
| Multidrug resistance‐associated protein 4 | ABCC4 | 0.65079 |
| IL‐1α | IL1A | 0.650269 |
| Catenin β‐1 | CTNNB1 | 0.64775 |
| Nuclease‐sensitive element‐binding protein 1 | YBX1 | 0.646298 |
| Aryl hydrocarbon receptor nuclear translocator | ARNT | 0.644848 |
| Kinase D‐interacting substrate of 220 kDa | KIDINS220 | 0.644789 |
| 40S ribosomal protein S23 | RPS23 | 0.642951 |
| Histone‐lysine N‐methyltransferase | EHMT1 | 0.642702 |
| Ras‐related protein Rab‐5C | RAB5C | 0.638376 |
| Choline transporter‐like protein 2 | SLC44A2 | 0.638143 |
| Heterogeneous nuclear ribonucleoprotein Q | SYNCRIP | 0.636071 |
| Programmed cell death protein 2 | PDCD2 | 0.635812 |
| Alkaline phosphatase, placental type | ALPP | 0.630986 |
| Rap1 GTPase‐GDP dissociation stimulator 1 | RAP1GDS1 | 0.629451 |
| Thrombospondin‐1 | THBS1 | 0.625131 |
| Serine/arginine‐rich splicing factor 6 | SRSF6 | 0.624837 |
| tRNA (guanine(26)‐N(2))‐dimethyltransferase | TRMT1 | 0.623349 |
| Importin subunit α‐3 | KPNA4 | 0.62148 |
| Keratin, type II cytoskeletal 80 | KRT80 | 0.621039 |
| 60S ribosomal protein L28 | RPL28 | 0.619835 |
| Vacuolar protein sorting‐associated protein 13A | VPS13A | 0.619703 |
| GSH peroxidase 1 | GPX1 | 0.619061 |
| Vacuolar protein sorting‐associated protein 13C | VPS13C | 0.617022 |
| Ribosomal L1 domain‐containing protein 1 | RSL1D1 | 0.614332 |
| Calpain‐7 | CAPN7 | 0.612377 |
| Protein CYR61 | CYR61 | 0.611353 |
| Multidrug resistance‐associated protein 1 | ABCC1 | 0.605965 |
| NEDD8 ultimate buster 1 | NUB1 | 0.603901 |
| F‐box‐like/WD repeat‐containing protein TBL1XR1 | TBL1XR1 | 0.596918 |
| Protein CutA | CUTA | 0.586437 |
| LIM and calponin homology domains‐containing protein 1 | LIMCH1 | 0.584768 |
| Protein PRRC2B | PRRC2B | 0.574416 |
| Periplakin | PPL | 0.566886 |
| Eukaryotic translation initiation factor 4B | EIF4B | 0.563664 |
| Dystonin | DST | 0.562774 |
| Protein HGH1 homolog | HGH1 | 0.55638 |
| Nucleoredoxin | NXN | 0.552367 |
| Polymerase I and transcript release factor | PTRF | 0.552291 |
| Histone H2B type 1‐D | HIST1H2BD | 0.549395 |
| Drebrin | DBN1 | 0.54526 |
| Basal cell adhesion molecule | BCAM | 0.543613 |
| Protein SCAF11 | SCAF11 | 0.541997 |
| Cyclin‐dependent kinase 6 | CDK6 | 0.536053 |
| Coiled‐coil domain‐containing protein 85C | CCDC85C | 0.534299 |
| Tropomyosin α‐1 chain | TPM1 | 0.526925 |
| Palladin | PALLD | 0.525911 |
| GSH peroxidase | GPX4 | 0.525253 |
| Eukaryotic translation initiation factor 5A‐1 | EIF5A | 0.518732 |
| CD276 antigen | CD276 | 0.517228 |
| Disabled homolog 2 | DAB2 | 0.505867 |
| PGF2 receptor negative regulator | PTGFRN | 0.490684 |
| Radixin | RDX | 0.488652 |
| Nuclear ubiquitous casein and cyclin‐dependent kinase substrate 1 | NUCKS1 | 0.465746 |
| mRNA‐capping enzyme | RNGTT | 0.439002 |
| Nesprin‐1 | SYNE1 | 0.41975 |
| Probable methyltransferase TARBP1 | TARBP1 | 0.396494 |
| Transferrin receptor protein 1 | TFRC | 0.34983 |
| Tropomyosin β chain | TPM2 | 0.34593 |
| YTH domain‐containing protein 1 | YTHDC1 | 0.330133 |
| Serine/threonine‐protein kinase | ULK4 | 0.016407 |