Figure 1.

FBXL10 was downregulated in the heart in STZ‐induced diabetic mice, in HG‐stimulated cardiomyocytes and H9c2 cells. (A) The expression of FBXL10 in STZ‐induced diabetic hearts were analyzed by Western blotting and normalized to β‐actin. Data represent the mean ± SD of three independent experiments. (B) The protein level of FBXL10 in cardiomyocytes was analyzed by Western blotting and normalized to β‐actin. Data represent the mean ± SD of three independent experiments. **, P < 0.01; *, P < 0.05. (C) Immunohistochemistry of FBXL10 in STZ‐induced diabetic hearts. Scale bar, 50 μm (n = 6). (D) H9c2 cells were treated with high glucose (HG, 33 mmol/L glucose), FBXL10 level was analyzed by Western blotting and normalized to β‐actin. Data represent the mean ± SD of three independent experiments. **P < 0.01; *P < 0.05