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Transmigration of melanoma cells through brain endothelial layers. Melanoma cells (A, C: B16/F10; B, D: A2058) were seeded on the top of confluent RBEC monolayers and left for 8 hours. (A and B) Electron micrograph series of transmigrating melanoma cells. (C and D) Representative transmission micrographs of melanoma cells migrated through the brain endothelial monolayer. Arrow = interendothelial junction, arrowhead = membrane protrusion, EC = endothelial cell
