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. 2019 Feb 7;23(4):2813–2821. doi: 10.1111/jcmm.14189

Figure 3.

Figure 3

SP‐1 mediated miR‐1258’s effect on cell growth and invasion. (A) MiR‐1258 decreased oral squamous cell carcinoma (OSCC) cell growth, while overexpression of SP‐1 counteracted this effect, as determined by MTT assay. (B) MiR‐1258 impaired OSCC cell colony formation ability, while SP‐1 restoration counteracted the effect. (C) MiR‐1258 delayed cell cycle progression from the G1 phase to S phase, whereas this effect was dismissed by SP‐1 restoration. (D) MiR‐1258 decreased cell invasion ability, which was offset by SP‐1 overexpression. (E) MiR‐1258 inhibited the EMT phenotype, while the effect was neutralized by SP‐1 overexpression