Figure 4.

LMK235 decreases aortic wall thickness in angiotensin II‐induced hypertensive mice and spontaneously hypertensive rats (SHRs). (A) Representative images of haematoxylin and eosin (H&E)‐stained thoracic aortas (scale bar, 50 μm). Ang II indicates angiotensin II‐infusion mice. (B) Aortic wall thickness was quantified from H&E staining (n = 8 per group). ***P < 0.001 vs control; ^### P < 0.001 vs Ang II. (C) H&E staining in vehicle‐treated WKY, vehicle‐treated SHRs and LMK235‐treated SHR aortas (scale bar, 50 μm). (D) Quantification of aortic wall thickness (n = 6 per group). ***P < 0.001 vs vehicle‐treated WKY; ^## P < 0.01 vs vehicle‐treated SHRs