Table 1.
Univariate and multivariate analysis of factors associated with survival and recurrence
| Variables | Overall survival | Relapse‐free survival | ||||
|---|---|---|---|---|---|---|
|
Univariate P value |
Multivariate |
Univariate P value |
Multivariate | |||
| HR (95% CI) | p value | HR (95% CI) | p value | |||
| Age, y (>52 vs ≤52) | 0.479 | NA | 0.513 | NA | ||
| Gender (male vs female) | 0.591 | NA | 0.671 | NA | ||
| HBsAg (positive vs negative) | 0.600 | NA | 0.482 | NA | ||
| Liver cirrhosis (yes vs no) | 0.920 | NA | 0.383 | NA | ||
| HCC family history (yes vs no) | 0.101 | NA | 0.091 | NA | ||
| AFP, ng/mL (>20 vs ≤20) | 0.004 | 1.55 (1.04‐2.30) | 0.030 | 0.002 | 1.76 (1.14‐2.71) | 0.010 |
| ALT, U/L (>75 vs ≤75) | 0.169 | NA | 0.050 | NA | ||
| γ‐GT, U/L (>54 vs ≤54) | <0.001 | 1.74 (1.17‐2.67) | 0.006 | <0.001 | 1.80 (1.15‐2.80) | 0.009 |
| Tumour size (>5 vs ≤5) | <0.001 | 1.96 (1.33‐2.91) | 0.001 | <0.001 | 1.91 (1.24‐2.94) | 0.003 |
| Tumour number (multiple vs single) | 0.195 | NA | 0.133 | NA | ||
| Tumour capsule (yes vs no) | 0.046 | NS | 0.055 | NA | ||
| Tumour differentiation (III‐IV vs I‐II) | 0.004 | NS | 0.002 | NS | ||
| Vascular invasion (Yes vs No) | <0.001 | 1.86 (1.27‐2.72) | 0.001 | <0.001 | 1.71 (1.12‐2.61) | 0.013 |
| EIF4E (high vs low) | 0.021 | NS | 0.002 | 1.67 (1.13‐2.45) | 0.010 | |
Univariate analysis was calculated by the Kaplan‐Meier method (log‐rank test). Multivariate analysis was done using the Cox multivariate proportional hazard regression model with stepwise manner (forward, likelihood ratio).
CI, confidential interval; HR, hazard ratio; NA, not adopted; NS, not significant.