Figure 1.

Post‐treatment of hypertensive mice with ATp300 inhibitors reverse hypertension‐induced ventricular wall thickness. Hypertension was induced by minipump‐mediated infusion of Angiotensin II in wild‐type mice. Minipump‐mediated saline infused mice were used as normotensive control. Angiotensin II‐induced hypertensive mice were treated with either DMSO (Group 2; n = 6); or C646 (Group 3, n = 6); or L002 (Group 4; n = 6) for 2‐wk on every 3rd day by intraperitoneal injection after 2 wk of saline or Angiotensin II minipump implantation. Saline‐infused mice were treated with DMSO (control) (Group 1; n = 6) (A). Blood pressures were recorded on weeks 2 and 4 (B) using tail‐cuff method. Echocardiogram was performed on week 4. Echocardiography showing images of the left ventricular wall thickness (LVWT) (C) and quantification data (D). The quantitative data of left ventricular end diastolic diameter (LVEDD) in four groups are shown in E. Heart weight to body weight are presented in F. ns, not significant; *P < 0.05; ***P < 0.005