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. 2019 Mar 19;10:223. doi: 10.3389/fphar.2019.00223

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Copyright © 2019 Vavers, Zvejniece, Maurice and Dambrova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Classical model for allosteric regulation of receptor. PAM, positive allosteric modulation; NAM, negative allosteric modulation. This Figure has been modified from Vavers (2017).