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. 2019 Mar 19;10:223. doi: 10.3389/fphar.2019.00223

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Copyright © 2019 Vavers, Zvejniece, Maurice and Dambrova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stabilization of the agonist state of Sig1R by PAMs. A model showing possible mechanisms of Sig1R ligand activity. (A) Oligomeric form. For the agonist state, (B,C) represent the dimeric and monomeric forms of Sig1R, respectively. This Figure has been modified from (Chu and Ruoho, 2016).