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. 2019 Mar 19;10:203. doi: 10.3389/fgene.2019.00203

Figure 1.

Figure 1

Androgenic-inducible miRNAs involved in the process of BC progression. (A) In Luminal A BC cells, DHT treatment induces an androgen-related miRNA-mRNA pathway, involving miR-363 and its possible target gene IQWD1. In the presence of high levels of androgens, a IQWD1 feed-forward regulation activates its own AR-mediated expression (Chen et al., 2007), and miR-363 significantly increased. Under relatively low level of DHT, IQWD1 is negatively regulated by miR-363. (B) In MA and TNBC cells, the DHT administration results in an androgen-induced AR activating signal pathway which upregulates let-7 expression and negatively regulates CMYC and KRAS that are targets of let-7. (C) In TNBC cells, the lncRNA ARNILA is negatively regulated by AR after DHT treatment, causing a decreased adsorption of miR-204 which in turn inhibits Sox4 expression, a gene known to promote EMT. (D) In TNBC cells, DHT induces upregulation of miR-328-3p with concomitantly decrease of its target CD44, diminishing EMT, migration and adhesion.