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Timeline of the study protocol. Blue segments: inpatient phases; Orange segments: multimodal assessments; Green segment: outpatient remote follow-up; dashed line: optional treatment extension; CRS-R, Coma Recovery Scale-Revised; NCS-R, Nociception Coma Scale-Revised; EEG, electroencephalography; PET, positron emission tomography; MRI, magnetic resonance imaging; T°, body core temperature; GOS-E, Glasgow Outcome Scale-Extended; Red crosses, 24 h EEG.
