Table 5.
The polyphenol compounds investigated for their action on α-synuclein fibrillation, aggregation, and cytotoxicity.
| Polyphenolic compounds | References |
|---|---|
| Apigenin, baicalein, (-)-catechin, (-)-catechin gallate, chlorogenic acid, curcumin, cyaniding, daidzein, delphinidin, 2,2′-dihydroxybenzophenone, 4,4′-dihydroxybenzophenone, dopamine chloride, (-)-epicatechin, (-)-epicatechin 3-gallate, epigallocatechin, epigallocatechin gallate, exifone, (-)-gallocatechin, (-)-gallocatechin gallate, gingerol, gossypetin, hinokiflavone, hypericin, kaempferol, luteolin, myricetin, naringenin, 2,3,4,2′,4′-pentahydroxybenzophenone, procyanidin B1, procyanidin B2, Purpurogallin, quercetin, rosmarinic acid, rutin, (+)-taxifolin, 2,2′,4,4′-tetrahydroxybenzophenone, theaflavine, (+)-R-tocopherol, 2,3,4-trihydroxybenzophenone (39 polyphenols) | Masuda et al., 2006 |
| Quercetin (3,5,7,3′,4′-Pentahydroxyflavone dehydrate), Fisetin (3,7,3′,4′-Tetrahydroxyflavone), T-601 (3′,4′-Dihydroxyflavonol), 22-344 (3,6,3′,4′-Tetrahydroxyflavone), 22-318 (3,6,2′,3′-Tetrahydroxyflavone), G-500/Gossypetin (3,5,7,8,3′,4′-Hexahydroxyflavone), C-101/Myricetin (3,5,7,3′,4′,5′-Hexahydroxyflavone), Rutin (Quercetin-3-rutinoside), K-102/Kaempferol (3,5,7,4′-Tetrahydroxyflavone), 020065/Isorhamnetin (3′-Methoxy-3,5,7,4′-Tetrahydroxyflavone), 020067/Galangin (3,5,7-Trihydroxyflavone), 021140S/Tamarixetin (4′-Methoxy-3,5,7,3′-Tetrahydroflavone), 22-324 (6,2′,3′-Trihydroxyflavone), D-406 (2′,3′-Dihydroxyflavone), D-258 (3′,4′-Dihydroxyflavone), D-116 (5,6-Dihydroxy-7-Methoxyflavone), 22-357 (5,6-Dihydroxyflavone), 22-336 (6,7,3′-Trihydroxyflavone), D-112 (6,7-Dihydroxyflavone), Luteolin (5,7,3′,4′-Tetrahydroxyflavone), 22-340/Tricetin (5,7,3′,4′,5′-Pentahydroxyflavone), 22-341 (7,3′,4′,5′-Tetrahydroxyflavone), 021165/6-HP (5,6,7,4′-Tetrahydroxyflavone), B-101/Baicalein (5,6,7-Trihydroxyflavone), 22-323 (6,2′,3′-Trimethoxyflavone), D-407 (2′,4′-Dihydroxyflavone), 021104S/Chrysoeriol (4′,5,7-Trihydroxy-3′-Methoxyflavone0, 021108S/Diosmetin (5,7,3′-Trihydroxy-4′-Methoxyflavone), Wogonin (5,7-Dihydroxy-8-Methoxyflavone), H-114 (3′-Hydroxy-5,6,7,4′-Tetramethoxyflavone), Epigallo Catechin Gallate (EGCG) [(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)], Epicatechin gallate (ECG) [(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)], 020976S/Catechin [(+)-3,3′4′,5,7-Flavanepentol (2H)-benzopyran-3,5,7-triol/(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1], T-116 (6,7,4′-Trihydroxyisoflavone), T-415 (7,3′,4′-Trihydroxyisoflavone), 19-612 (3′,4′-Dimethoxy-7-hydroxyisoflavone), D-101/Daidzein (7,4″-Dihydroxyisoflavone), F-103/Formononetin (7-Hydroxy-4′-methoxyisoflavone), Biochanin A (5,7-Dihydroxy-4′-methoxyisoflavone), 020056/Eriodictyol (2-[3,4-Dihydroxyphenyl] 2,3-dihydro-5,7-dihydroxy-4H-1benzopyran-4-one), H-103/Hesperetin (5,7,3′-Trihydroxy-4′-methoxyflavanone), 020091/Homoeriodictyol (5,7,4′-Trihydroxy-5′-methoxyflavanone), Hesperidin/Hesperetin-7-O-rutinoside, 020411/Alizarin (1,2-Dihydroxyanthraquinone), Chrysophanol (1,8-Dihydroxy-3-methylanthraquinone), Emodin (1,3,8-Trihydroxy-6-methylanthraquinone), D-105/Fustin (3,7,3′,4′-Tetrahydroxyflavone), 021037 (3,3′,4′,5′,7-Pentahydroxyflavanone) (48 polyphenols) |
Meng et al., 2010 |
| Apigenin, baicalein, epigallocatechin gallate, genistein, ginkgolide B, morin, myricetin (Myr), nordihydroguaiaretic acid, purpurogallin trimethyl ether, quercetin, resveratrol, rosmarinic acid, scutellarein, tannic acid, theaflavins (14 polyphenols) |
Caruana et al., 2011 |
| Apigenin, baicalein, EGCG, genistein, ginkgolide B, morin, nordihydroguaiaretic acid, propyl gallate, purpurogallin trimethyl ether, resveratrol, scutellarein, and black tea extract (BTE; >80% theaflavins) (12 polyphenoilc compunds) | Caruana et al., 2012 |
| Benzoic acid and derivatives, such as 2-Hydroxybenzoic acid (salicylic acid), 3-Hydroxybenzoic acid, 4-Hydroxybenzoic acid, 2,3-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid (gentisic acid), 2,6-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 2,4,6-trihydroxybenzoic acid, 3,4,5-trihydroxybenzoic acid (gallic acid), 3,4,5-trihfluorobenzoic acid, 3,4,5-trimethoxybenzoic acid, 4-methoxybenzoic acid (Benzoic acid derivatives) |
Ardah et al., 2014 |
| Myricetin, curcumin, rosmarinic acid, nordihydroguaiaretic acid, and ferulic acid | Takahashi et al., 2015 |
| Curcumin, baicalein, (-)-epigallocatechin gallate, and resveratrol | Gautam et al., 2017 |