Pyramidal cells and interneurons express voltage-dependent membrane input resistance and time constant values that scale membrane voltage fluctuations. A, B, Example traces of pyramidal cell (A) and interneuron (B) membrane voltage in response to step hyperpolarizations at different membrane voltages (ii). C, D, Average membrane input resistance (i) and time constant (ii) values measured between −90 and −50 mV for pyramidal cells (C) and interneurons (D). E, Plot of normalized membrane SD as a function of normalized input resistance for pyramidal cells (i) and interneurons (ii). iii, Plot of absolute membrane resistance near rest and the corresponding SD of membrane voltage at the same voltage for pyramidal cells and interneurons. F, Average ratio between normalized resistance and SD measured at different membrane voltages for pyramidal cells (i) and interneurons (ii), along with the maximum value for the ratio in each cell type (iii).